Thomas Gildea, MD, the pulmonologist and Section Head of Bronchology in Cleveland Clinic’s Respiratory Institute, created 3D-printed patient-specific stents for patients with chronic respiratory diseases. He discusses the road to FDA approval, the plan to get the stent to patients who need it the most and more.
New Genetic Test May Mean Better Outcomes in Advanced Prostate Cancer
A new test developed at Cleveland Clinic interrogates the HSD3B1 gene to determine if a prostate cancer patient has inherited the adrenal-permissive (1245C) or adrenal-restrictive (1245A) allele. The development of the test is an outgrowth of more than seven years of research at Cleveland Clinic.
COVID-19 and ACE2: Are ARBs and ACEIs Helpful or Harmful?
We share a practical overview of the question, including current recommendations on continuing use of RAAS antagonists and potential therapeutic approaches related to the ACE2 receptor.
COVID-19: When Caregivers Come Home to Their Families
Steven Gordon, MD, Chair of Infectious Disease in Cleveland Clinic’s Respiratory Institute, discusses ways healthcare workers can prevent the spread of COVID-19 to their families.
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Long-Term Outcomes of Repeat Epilepsy Surgery: Insights from the Largest Study to Date
Sustained seizure control is achievable in this setting, but chances of success decrease with each successive reoperative attempt, regardless of other clinical factors.
Gender Disparity Greater Than Expected in Leadership of Cardiovascular Clinical Trials
A review of recent major cardiovascular medicine studies reveals that only 1 in 10 first authors, senior authors and trial leadership committee members are women.
New Blood Test Detects Multiple Cancer Types with High Accuracy
A prototype blood-based screening test evaluated by Cleveland Clinic researchers and others can accurately detect and localize multiple types of cancer, often before symptoms show. The promising results raise hopes that the assay will help achieve the long-sought goal of population-scale early detection of cancer.
COVID-19: Implications for Managing Inflammatory Bowel Disease
As of March 25, 2020, there were 87 reports of patients with IBD and COVID-19 in the international Surveillance Epidemiology of Coronavirus Under Research Exclusion database (SECURE-IBD).
Advances in the Diagnosis of Central Nervous System Vasculitis
Arriving at a diagnosis of CNS-V is fraught with challenges. There is no classic presentation, the condition has several mimics, brain tissue is inaccessible and there is no disease-specific test. However, advances in neuroimaging and next-generation sequencing have added formidably to our knowledge of CNS-V.
A Pediatric Case of Plastic Bronchitis Resolved with Right Heart Overhaul
Plastic bronchitis typically develops after Fontan palliation of single-ventricle physiology. This case offers a lesson in its management in a rare setting: right-sided heart failure in a child with two ventricles.