IMmotion151 compared therapy with atezolizumab, a monoclonal anti-body of IgG1 isotype against PD-L1, and bevacizumab, an anti-VEGF monoclonal antibody approved to treat many cancer types, with sunitinib.
Immunotherapy Vaccine Improves Survival Rates in Patients with Glioblastoma
A phase 2 trial demonstrates promising results in patients with glioblastoma who take SurVaxM, an immunotherapy vaccine that targets survivin.
Intracystic Glucose Levels Offer Good Accuracy for Differentiating Precancerous Mucinous from Benign Nonmucinous Pancreatic Cysts
Cleveland Clinic researchers present study at DDW 2018 which found that measuring intracystic glucose levels was more accurate than current testing protocols for distinguishing between precancel mucinous cysts and benign nonmutinous cysts.
Familial Melanoma Diagnosis Can Signal Higher Risk for Other Cancers
People with a higher incidence of cancer — multiple melanomas, melanoma and additional cancers or a family history of melanomas and other malignancies — can carry a higher risk for breast, pros-tate, brain and other cancers.
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T-DM1 + Neratinib’s Safety and Efficacy in Women with Metastatic HER2+ Breast Cancer
Results of a multi-institutional phase 1b clinical trial show women with metastatic HER2+ breast cancer respond well to the combina-tion of trastuzumab emtansine and neratinib.
ALLELE: Guiding Glioblastoma Treatment with Tumor Genetics
Cleveland Clinic researchers are part of a new effort to generate prospective clinical genomics that inform treatment decisions in patients with glioblastoma
In Patients with Left Bundle Branch Block, What’s the Best Test for CAD?
Current guidelines recommend exercise stress echo, but it can’t reliably detect significant obstructive CAD in patients with LBBB at rest. We share nuanced recommendations for alternatives.
Radical Perineal Prostatectomy Makes a Comeback Thanks to Robotics
Robotic RPP offers a variety of advantages for surgeon and patient, especially more direct access to the prostate. It’s gaining traction in the U.S. and has now debuted in Europe.
Healthcare Costs: We Must Do Better
The CEO of Cleveland Clinic Florida argues that healthcare costs should not cause undue hardship, and reflects on the ethical responsibilities of physicians.
Alzheimer Dementia: Starting, Stopping Drug Therapy
Cognition-enhancing drugs and psychotropic drugs for behavioral symptoms of Alzheimer disease need to be continuously evaluated for clinical efficacy.