The immune checkpoint inhibitor atezolizumab showed promising, lasting efficacy in patients with locally advanced or metastatic urothelial cancer, according to results of a phase II clinical trial conducted by an international team including Cleveland Clinic Cancer Center oncologist Petros Grivas, MD, PhD. The findings represent the first significant improvement in the systemic treatment of metastatic urothelial cancer in 30 years.
Heated chemotherapy (HIPEC) plus cytoreductive surgery can extend survival and reduce morbidity in patients with many forms of advanced abdominal cancer.
Cigarette smoking remains a major factor in reducing semen quality in adult men, a new study has verified, despite significant changes to the criteria that laboratories worldwide are supposed to use to evaluate semen samples and assess fertility.
New research shows the angiogenic factor AGGF1 is a highly effective treatment in a mouse model of acute MI, thanks to a cellular housekeeping process called autophagy. The findings pave the way for human trials.
In children with early focal brain lesions, nonlocalized EEG patterns such as hypsarrhythmia are not absolute contraindications to epilepsy surgery. Here’s a case in point.
Sixty percent of American hospitals are losing money and are seeking ways to leverage strengths, and discovering new economies of scale and scope. Cleveland Clinic’s merger in Akron is an example of how this can work.
A new meta-analysis finds that giving a vitamin K antagonist in the three months after bioprosthetic valve implantation yields no benefits while raising the risk of a major bleed.
A new technology allows providers and students to move a holographic model of the body and peer into it from angles that even the most experienced surgeons can only see in their wildest dreams.
With increasing genetic insights into hereditary breast cancer, clinicians must decide which of a variety of diagnostic and prognostic genetic test they should offer patients and their families. Holly Pederson, MD, Director of Cleveland Clinic’s Medical Breast and Hereditary High-Risk programs, discusses the choices.
Novel endovascular navigation technology constructs a 3-D model to guide minimally invasive aortic repairs without radiation-inducing fluoroscopy. It just succeeded in its first preclinical study.