Thrombotic Thrombocytopenic Purpura: The Role of ADAMTS13

Thrombotic thrombocytopenic purpura (TTP) diagnosis is often difficult because of atypical presentations and signs and symptoms that resemble other conditions. Measurements of ADAMTS13 activity, ADAMTS13 inhibitor and ADAMTS13 autoantibody are useful for diagnosing TTP, guiding therapy and predicting relapse.