The presence of chronic obstructive pulmonary disease in patients with chronic kidney disease greatly increases the risk of death, a Cleveland Clinic study has found. The results demonstrate the importance of closely monitoring chronic kidney disease patients with respiratory comorbidities.
With sudden cardiac death an increasing risk as kidney disease progresses, CKD patients would seem to gain from implantable defibrillators. But a Cleveland Clinic analysis shows that the device’s mortality reductions don’t extend to patients in end-stage CKD.
A Cleveland Clinic analysis shows heart disease and cancer are main causes of death in non-dialysis-dependent chronic kidney disease patients, with reduced renal function linked to higher risk for cardiovascular mortality. Blacks with mild to moderate CKD have higher risk of cardiovascular deaths than do whites.
An analysis of data from the Chronic Renal Insufficiency Cohort shows a high rate of treatment-resistant hypertension among chronic kidney disease patients, increasing their risk for adverse cardiovascular and renal outcomes. Screening and intervention are vital.
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A recent study has found that in patients with stage 3 to 4 chronic kidney disease, mortality levels are lowest when serum potassium levels are kept between 4 and 5 mmol/L.
Cleveland Clinic studies show that in men with renal disease, reduced levels of serum testosterone are associated with an increased mortality risk compared with higher testosterone levels. Low serum testosterone level following kidney transplant also predicts increased risk of death and graft loss. Low T merits study as a biomarker for disease severity and as a target for replacement therapy.
Six percent of Americans have both chronic kidney disease and metabolic syndrome. A Cleveland Clinic study looks for associations among metabolic syndrome, end stage renal disease and death.
The quantity of preserved nephrons correlates directly with functional recovery after partial nephrectomy. Precision of tumor excision and renal reconstruction to save as much vascularized parenchyma as possible is critical and can be optimized by high-quality imaging and meticulous surgical technique.
Accurate renal function measurement is critical to predict long-term adverse outcomes after nephrectomy. The relationship between chronic kidney disease and poor clinical outcomes is robust, but prediction can be improved by incorporating proteinuria.
A look into Cleveland Clinic’s chronic kidney disease registry uncovers risks of increasing levels of serum alkaline phosphatase