An expert group is advocating that MS be characterized based on underlying biological processes rather clinical disease course. One of the experts explains the rationale and implications.
New research finds that TREM2 deficiency during viral-induced demyelination dysregulates expression of genes regulating phagocytic pathways and lipid metabolism, with distinct effects on recovery.
Cortical changes other than demyelination appear to exert more influence on conventional MRI modalities, finds a new postmortem MRI study. Better acquisition and post-processing methods are needed.
An autopsy study has shown for the first time that neuronal degeneration can occur independently of white matter demyelination in the MS brain. The researchers discuss implications.
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In multiple sclerosis, blocking the source — rather than the target — of excitotoxic glutamate is a more feasible therapeutic strategy for CNS protection. Neuroscientist Tara DeSilva, PhD, explains why, along with the research implications.