Cortical changes other than demyelination appear to exert more influence on conventional MRI modalities, finds a new postmortem MRI study. Better acquisition and post-processing methods are needed.
An autopsy study has shown for the first time that neuronal degeneration can occur independently of white matter demyelination in the MS brain. The researchers discuss implications.
In multiple sclerosis, blocking the source — rather than the target — of excitotoxic glutamate is a more feasible therapeutic strategy for CNS protection. Neuroscientist Tara DeSilva, PhD, explains why, along with the research implications.