Application of the novel framework has identified the dyslipidemia medication gemfibrozil as a candidate drug to reduce Alzheimer’s disease risk.
A multifront Cleveland Clinic research project aims to use $14 million in NIH funding to identify mechanisms and targets underlying AF that may lead to personalized therapies.
The development of treatment resistance in cancer is driven by the same evolutionary mechanisms that drive change and escape from therapy in most human diseases.
New survivorship program helps patients transition from cancer treatment to recovery while addressing their future risks through next-generation sequencing.
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New virtual genomics clinic provides custom-tailored cancer treatments by targeting specific molecular alterations in patients’ tumors.
Cleveland Clinic now offers an advanced genomic testing platform as standard of care to patients with cancer. This expanded capability turns cancer treatment into a “stealth bullet” that allows clinicians to identify genetic defects and connect patients with individualized, lifesaving therapies.
New funding will expand the LARGE-PD cohort study of Parkinson disease in Latinos to include a genome-wide association study and develop a Latino-specific polygenic risk score for PD.
Timothy Chan, MD, PhD, the renowned cancer researcher who directs Cleveland Clinic’s new Center for Immunotherapy and Precision Immuno-Oncology, plans to use genomic analysis and high-throughput immunoprofiling to develop advanced targeted therapies.
Cleveland Clinic’s Genomic Medicine Institute is looking at the use of sophisticated 3-D modeling to help discern nuanced but important structural differences between germline PTEN variants associated with and predictive of a patient’s clinical condition.
A genetic mutation found only in individuals of African descent confers higher risk of chronic kidney disease. It could also be key in reducing transplant rejection.