When dietary choline and L-carnitine meet gut flora, the result is TMAO — and much unhealthful mischief. New research shows the damage goes beyond atherosclerosis to heart failure, chronic kidney disease and maybe more.
What do gut flora and the proliferation of percutaneous procedures have in common? They both figure into discoveries or changes from our list of 50 key developments in cardiovascular care over the past two decades.
Further research revealed heart failure patients with elevated plasma levels of TMAO, a metabolite generated in the gut, have a higher mortality risk than patients with lower TMAO levels.
Researchers have found that a biochemical mechanism is at work between gut microbes and cholesterol that can lead to an increased risk of heart disease. They are looking more closely at a meat based diet vs. a plant based diet. Building on years of previous work, Dr. Hazen Stanley Hazen, Cleveland Clinic, and a research team are tracking the substance TMAO produced by the liver that is found to have an impact on negative cardiac outcomes.