A factor in the pathophysiology of Chiari malformation may be the movement of cerebrospinal fluid and brain tissue during the cardiac cycle. Cerebrospinal fluid and brain dynamics can normalize with surgical decompression.
Hydrocephalus: Can We Help the Brain Adapt to a Chronic Squeeze?
Chronic hydrocephalus is accompanied by a high level of cognitive function. Cleveland Clinic Children’s Center for Pediatric Neurology and Neurosurgery has been looking at the angiogenic response and VEGF.