Rheumatologists should be aware of the high rate of mortality associated with Pneumocystis pneumonia and use preventive strategies in at-risk patients, such as those on an immunosuppressive-induction regimen.
Few tests have the ability to detect and potentially prevent organ and life-threatening disease the way urinalysis can. With small vessel vasculitis, its ability to detect glomerulonephritis early is particularly valuable.
In older Wegener’s patients, outcome is influenced by comorbid illnesses and enhanced risk for medication toxicities. Proactive monitoring and patient education play an important role in optimizing the potential for recovery.
Identifying reliable biomarkers of disease activity in granulomatosis with polyangiitis is the goal of a collaboration between Cleveland Clinic and Case Western Reserve University
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Cleveland Clinic Children’s Center for Pediatric Rheumatology has developed a nationally recognized comprehensive evaluation and treatment service for children with chronic vasculitis.
Few clinicians are highly experienced with central nervous system vasculitis. Having a diverse team of experts who are familiar this disease and its mimics helps ensure an accurate diagnosis and workup
Study findings support the addition of a conventional maintenance agent, in the absence of contraindications, with rituximab to reduce the risk of relapse in granulomatosis with polyangiitis patients.
Giant cell arteritis, Takayasu’s arteritis and isolated aortitis have been seen as separate diseases distinguished by age at onset and pattern of vessel involvement, but they may be more similar than previously known.
Giant cell arteritis and Takayasu’s arteritis may not be separate diseases but rather skewed phenotypes of a single disease, influenced by genetics, age-related structural changes, immunologic senescence and environment.
Addition of a conventional maintenance agent to rituximab and glucocorticoids reduced the incidence of GPA relapse without resulting in a higher incidence of adverse events in study.