Studying the relationship between autism spectrum disorder and cancer in individuals affected by PTEN hamartoma tumor syndrome is the subject of a new $2 million grant awarded from the National Institutes of Health to Charis Eng, MD, PhD, Chair of the Genomic Medicine Institute.Read More
Prediction Model Aids in the Early Diagnosis of Dravet Syndrome
The tool’s utility in distinguishing Dravet syndrome from milder genetic epilepsies promises earlier intervention to attenuate risk of cognitive effects in the youngest children.
Launch of Cleveland Clinic Brain Study Marks Unprecedented Effort to Disrupt Neurological Diseases
This landmark prospective investigation aims to study up to 200,000 healthy individuals over 20 years to identify brain disease biomarkers and targets for preventing and curing neurological disorders.
The Promise of Gene Therapy in Neurological Disorders (Podcast)
Our newest Neuro Pathways podcast episode spotlights advances in genomic research that show promise for targeted gene therapy for conditions from neurodegenerative diseases to epilepsy.
New Clinic Helps Cancer Patients Decipher Results of Genome Sequencing
New virtual genomics clinic provides custom-tailored cancer treatments by targeting specific molecular alterations in patients’ tumors.
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Cleveland Clinic Expands Cancer Genomic Testing Capabilities
Cleveland Clinic now offers an advanced genomic testing platform as standard of care to patients with cancer. This expanded capability turns cancer treatment into a “stealth bullet” that allows clinicians to identify genetic defects and connect patients with individualized, lifesaving therapies.
Machine Learning Model Uses Clinical and Genomic Data to Predict Immune Checkpoint Blockade Effectiveness
A computer model developed by Cleveland Clinic oncologist Timothy Chan, MD, PhD, and colleagues accurately predicts whether immune checkpoint blockade will be effective in patients diagnosed with a wide variety of cancers.
Utility of Genomic-Adjusted Radiation Dose as a Pan-Cancer Predictor of Radiation Therapy Benefit
A group of researchers led by Jacob Scott, MD, DPhil, have validated a quantifiable, genomically guided parameter that serves as a predictor of the therapeutic benefit of RT for each individual patient.
LARGE-PD Study Begins to Profile the Genetics of Parkinson’s Disease in Latinos
The first genome-wide association study of Parkinson’s disease in Latinos has identified several potential risk loci of interest in this understudied population.
Breastfeeding Cuts Ovarian Cancer Risk in BRCA Mutation Carriers
A history of breastfeeding is associated with a 23% reduction in the risk of ovarian cancer among women who carry BRCA1 or BRCA2 mutations.
Study Suggests Mechanistic Overlap Between Alzheimer’s and COVID-19
A network medicine study has identified mechanisms by which COVID-19 can lead to dementia-like cognitive impairment. The findings may help inform risk management and treatment strategies for COVID-19-linked dementia.