New research finds that TREM2 deficiency during viral-induced demyelination dysregulates expression of genes regulating phagocytic pathways and lipid metabolism, with distinct effects on recovery.
Read MoreWhat’s the State of Anti-Amyloid Therapy in the Wake of Initial Clarity AD Findings?
Two brain health experts discuss what the prominent study results mean for the amyloid hypothesis and what to expect next in both clinical practice and the research landscape.
First-of-Kind Review Reveals Notable Climate Change-Related Impacts on Neurologic Health
A scoping literature review finds climate change and airborne pollution to be associated with the incidence and severity of a number of neurologic diseases. The authors recommend how clinicians and researchers can respond.
Central Vein Sign on FLAIR* MRI Comparable to CSF Oligoclonal Bands for Diagnosing MS
The finding of equivalence in diagnostic accuracy raises hopes for an eventual noninvasive means for reliable early diagnosis of multiple sclerosis.
Phase 1 Trial Shows Drug-Resistant Immunotherapy for Glioblastoma Is Safe and Feasible
This novel approach involves injecting supercharged immune cells directly into the tumor cavity in the brain. Encouraging initial findings have set the stage for the launch of phase 2 testing.
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Researchers Advance Novel Studies of Hidden Brain Threats in Acute Liver Failure
Multidisciplinary researchers are charting new territory in the understanding of how cerebral autoregulation is impaired in patients with advanced liver failure.
Understanding and Managing Moyamoya Disease (Podcast)
An expert in this rare cerebrovascular disorder shares insights on how to avoid the common pitfalls of misdiagnosis and delayed treatment.
Study Underscores Need to Optimize Pharmacotherapy After Neuro ICU Discharge
A study of a novel virtual clinic for patients discharged from the neuro ICU shows that these patients receive frequent pharmacotherapy adjustments. The findings highlight opportunities to optimize outcomes and curb adverse events in a high-risk population.
Big Patient Data Analyses Pinpoint Telmisartan as a Candidate Drug for Alzheimer’s in Black Adults
A combination of pharmacoepidemiologic studies and Mendelian randomization genetic analysis revealed preferential protection in Black but not white individuals. The findings support ongoing studies of telmisartan for Alzheimer’s, particularly in racially diverse cohorts.
Case Study: The Overlap of Complex Regional Pain Syndrome and Functional Neurologic Disorder in Pediatrics
Complex regional pain syndrome and functional neurologic disorder can present with clinical similarities, but differentiating between the diagnoses is critical to optimize outcomes.
Managing Increased Demand for Adolescent Psychiatric Services (Podcast)
The leader of our Section of Child and Adolescent Psychiatry shares strategies and lessons from how Cleveland Clinic is striving to meet burgeoning mental healthcare needs among young patients.