Glioblastoma cells use mitochondria from the central nervous system to grow and form more aggressive tumors, a new study finds. The finding suggests new opportunities for therapeutic development.Read More
Key Component in Hemoglobin Maturation Process Identified
New findings allow researchers to better identify potential problems in blood development, with potential for use in developing treatments for cancer and blood diseases.
Where You Live Can Affect Your Health: A National Analysis of ESRD Patients
Investigators found that patients with ESRD living in areas with lower residential life expectancy had significantly poorer health outcomes and reduced incidence of important processes of care compared to patients living in higher life expectancy areas.
Prosthetic Function Advances with First Demonstration of Illusory Movement Perception in Amputees
New research provides a critical new element that could soon lead to fully integrated and efficient prosthesis control. The lead investigator explains the backstory and implications.
Cisplatin + Experimental Drug Highly Effective Against Small Cell Lung Cancer
Cisplatin and CBL0137 work synergistically to attack a combination of three different cellular pathways that contribute to chemotherapy resistance.
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WAVE3-YB1 Interaction Regulates Cancer Stem Cell Activity in Breast Cancer
A WASP/WAVE actin-cytoskeleton remodeling protein plays a major role in chemoresistance in triple-negative breast cancers.
“GPS System for the Operating Room” to Be Tested in Patient-Specific Models
Researchers will use Microsoft’s HoloLens and an application for the mixed reality technology to visualize surgery in true 3-D.
Pro-Collagen Pathway Regulated by MAS and CTGF May Promote Heart Failure
A study of human cardiac tissue shows that CTGF mediates the profibrotic effects of MAS in cardiac fibroblasts. The findings suggest a promising target for heart failure drug intervention.
Reversal of Alzheimer’s in Mouse Model Boosts BACE1 Inhibitors’ Prospects in Humans
By demonstrating the most dramatic reversal of amyloid deposition in an Alzheimer’s disease mouse model to date, a new study gives renewed support to the BACE1 inhibitor class in human trials.
New Signaling Pathway May be Key to Preventing Diet-Related Obesity
For the first time, research suggests that Akt3 protects against diet-related obesity in a preclinical model by suppressing a mechanism of adipogenesis. Eugene Podrez, MD, PhD, explains.
How Cancer Stem Cells Drive Triple-Negative Breast Cancer
A new study the Department of Cellular and Molecular Medicine identifies a never-before described survival pathway in cancer stem cells (CSCs) that may serve as a potential target for new triple-negative breast cancer (TNBC) treatment therapies.