A Cleveland Clinic research team has discovered how a protein on the surface of immune system mast cells in the lungs facilitates the cells’ proliferation, contributing to severe inflammation and progression to asthma. Although more research is needed to fully understand mast cell hyperproliferation, inhibiting the surface protein known as MCEMP1 could be a new approach to treating asthma and other inflammatory lung conditions.Read More
Platelet Olfactory Receptor Identified as Possible AAA Biomarker and Treatment Target
Blocking a newly discovered olfactory membrane receptor has been shown to reduce platelet reactivity in abdominal aortic aneurysms (AAAs), raising the prospect of therapeutic targeting to stop AAA progression.
Pair of NIH Grants to Probe Multiple Sclerosis Pathogenesis on Two Fronts
One of our neuroscientists is investigating a potential link between the circadian cycle and remyelination as well as exploring the molecular basis of thalamic volume atrophy.
Salivary miRNAs Show Potential as Noninvasive Biomarkers of Hepatocellular Carcinoma
MicroRNA molecules associated with hepatocellular carcinoma are present and detectable in saliva and hold promise as highly sensitive and noninvasive biomarkers of the disease, Cleveland Clinic investigators have found.
SARS-CoV-2 Infection During Pregnancy Creates Immune Changes
Cleveland Clinic researchers investigated how COVID-19 infection during pregnancy affects mothers and their infants. The results indicate the need for long-term follow-up to catch any unforeseen health conditions related to the infection.
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New Study Uses Unique Approach to Gain Insight into Sarcopenia and Liver Disease
Using a multifaceted approach, Cleveland Clinic researchers have discovered molecular pathways that illuminate hyperammonemia’s role in the pathogenesis of sarcopenia, laying the groundwork for future therapies.
New Collaboration Moves the Needle on Precision Medicine
Cleveland Clinic teams with PDGx to harness the diagnostic power of liquid biopsy and increase the use of precision diagnostics within the cancer care continuum.
Failed Alzheimer’s Drug Shows Promise for Treating Glioblastoma in Preclinical Study
Treatment of preclinical models of glioblastoma with a BACE1 inhibitor reprogrammed tumor-promoting macrophages into tumor-suppressing macrophages, destroying tumor cells in the process.
Immune Checkpoint Inhibitors May Enhance Cancer-Associated Thrombosis
New research shows that immune checkpoint inhibitors can enhance cancer-associated thrombosis in murine models of colon carcinoma.
Sildenafil Emerges as a Candidate Drug for Alzheimer’s Disease
A large insurance database analysis has found a 69% relative risk reduction for Alzheimer’s development over six years, prompting mechanistic and phase 2 randomized studies.
Dietary Nitrate Exerts Differing Platelet Effects in Men and Women
Dietary nitrate — found in green leafy vegetables and other healthy foods — appears to inhibit platelet activation in women while increasing it in men, suggests a hypothesis-generating study.