A team of scientists from Cleveland Clinic’s Lerner Research Institute, Johns Hopkins University School of Medicine and Johns Hopkins Drug Discovery has synthesized and tested a new class of gut-restricted oral therapies that shows promise in treating inflammatory bowel disease.
Read MoreEarly Cancer Drug May Help Fight Multidrug-Resistant Bacteria
A topical application of PALA, a chemotherapy no longer in use, improves the clearance of resistant bacteria in human skin.
DoD Awards $2.5M for Improving Spinal Cord Injury in Rehabilitation
Cleveland Clinic researchers are trying to speed recovery from spinal cord injury using noninvasive brain stimulation.
Understanding the Preeclampsia-Thrombophilia Connection
Cleveland Clinic researchers identify pro-inflammatory, pro-coagulant proteins and particles that are released from placental cells in preeclampsia.
Preventing a Common Hospital-Acquired Infection
New research suggests that supplementing antibiotic therapy with a butyrate-producing probiotic and prebiotic may make the gut environment unfriendly to C. diff and prevent CD infection.
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Where You Live Can Affect Your Health: A National Analysis of ESRD Patients
Investigators found that patients with ESRD living in areas with lower residential life expectancy had significantly poorer health outcomes and reduced incidence of important processes of care compared to patients living in higher life expectancy areas.
Cisplatin + Experimental Drug Highly Effective Against Small Cell Lung Cancer
Cisplatin and CBL0137 work synergistically to attack a combination of three different cellular pathways that contribute to chemotherapy resistance.
WAVE3-YB1 Interaction Regulates Cancer Stem Cell Activity in Breast Cancer
A WASP/WAVE actin-cytoskeleton remodeling protein plays a major role in chemoresistance in triple-negative breast cancers.
“GPS System for the Operating Room” to Be Tested in Patient-Specific Models
Researchers will use Microsoft’s HoloLens and an application for the mixed reality technology to visualize surgery in true 3-D.
New Signaling Pathway May be Key to Preventing Diet-Related Obesity
For the first time, research suggests that Akt3 protects against diet-related obesity in a preclinical model by suppressing a mechanism of adipogenesis. Eugene Podrez, MD, PhD, explains.
Researchers Discover Mechanism that Helps Turn a Subset of CD4+ Helper Cells into a Cancer-Fighting Tool
Cleveland Clinic researchers have pinpointed the transcription factor that regulates the differentiation of CD4+ helper cells into a subset that has anti-tumor effects.