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Balancing the Benefits of Biologic Therapy for Autoimmune Disease Against the Risks of Mycobacterial Infections

Tumor necrosis factor-α inhibitors (TNFis) have transformed care for rheumatoid arthritis and other autoimmune diseases, but they also are associated with higher risks of serious and opportunistic infections than traditional disease-modifying antirheumatic drugs. In this article, Cassandra Calabrese, DO, discusses balancing the benefits of biologic therapies with the risks of infection.

Extremely Rare Association of Anti-PM-Scl Antibody-Associated Systemic Sclerosis and Inclusion Body Myositis

Two female patients with anti-PM-Scl antibody-associated systemic sclerosis developed progressive proximal myopathy. Both patients had profound muscle weakness that was refractory to treatment with glucocorticoids with or without other oral immunosuppressants. In this article, rheumatologist Souyma Chatterjee, MD, shares two cases of anti-PM-Scl antibody-associated scleromyositis in which a muscle biopsy unexpectedly showed features of sporadic inclusion body myositis.

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Polymyalgia Rheumatica-Like Syndrome from Checkpoint Inhibitor Therapy

Is checkpoint inhibitor-related polymyalgia rheumatica (PMR) distinct from the classic rheumatic disease, or does it represent new clinical variants with potentially different pathogenesis, clinical course and treatment responsiveness? Rheumatologist/immunologist Cassandra Calabrese, DO, discusses her research, which identified clinical features that are unusual in idiopathic PMR.