When a 35-year-old presented with pharmacoresistant epilepsy, SEEG and cortico-cortical evoked potentials proved crucial in localizing a single focus and paving the way for seizure control through laser ablation.
Complex Cases Help Remind Us Why We Do What We Do
Regardless of your other roles, never lose sight of your fundamental role as a caregiver to patients. Taking stock of that role can be helpful at both the organizational and individual levels.
Information-Guided Neurological Care Is at Hand
An information-guided approach to care — involving brain mapping, image post-processing and more — is leading to enhanced diagnosis and more-personalized treatments in patients with complex neurological diseases.
Myelin PET: What It Is and How It Adds a New Dimension to Brain Mapping
A novel PET radiotracer binds preferentially to myelin to provide unique brain imaging advantages over existing MRI methods. Here’s an overview of its backstory and clinical potential.
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services Policy
Myelin PET: Pioneering Its Clinical Application in Epilepsy and Beyond
Myelin PET offers quantitative imaging of brain microstructure that goes beyond what’s seen with current MRI methods. Here’s how we’re using it in epilepsy — and how we’ll soon be using it in other CNS diseases.
SEEG Laser Ablation Brings Seizure Control in Difficult-to-Localize Epilepsy
In medically intractable focal epilepsy, absence of a lesion on brain MRI too often rules out epilepsy surgery. This case shows how advanced diagnostics can allow “MRI-negative” patients to benefit from surgery.
Case Study: SEEG-Guided Surgery Yields Success in Refractory Epilepsy with Multifocal Spikes
This case of highly refractory epilepsy shows that SEEG-guided localization and surgery can bring significant seizure relief even in the setting of generalized or multifocal interictal discharges.
Epilepsy: A Conversation with Imad Najm, MD
If patients with epilepsy don’t respond to one or more appropriately chosen medications, there may be a need for further, specialized treatment. Here, Imad Najm, MD, outlines alternative options for patients with epilepsy.
Probing Molecular Mechanisms of Epilepsy Progression
Recent Cleveland Clinic research shows increased expression of growth associated protein 43 (GAP-43) in dysplastic neurons, and an association between increased GAP-43 expression and longer epilepsy duration in patients with type II focal cortical dysplasia. These early findings suggest that GAP-43 may prove to be a pathology-specific biomarker for epileptogenicity and progression.
EEG-Correlated fMRI: A Promising Tool in the Multimodal Evaluation of Refractory Epilepsy
Combining scalp electroencephalography with functional magnetic resonance imaging may allow better understanding of the pathophysiologic mechanisms and patterns of epileptic activities.