When a 35-year-old presented with pharmacoresistant epilepsy, SEEG and cortico-cortical evoked potentials proved crucial in localizing a single focus and paving the way for seizure control through laser ablation.
Regardless of your other roles, never lose sight of your fundamental role as a caregiver to patients. Taking stock of that role can be helpful at both the organizational and individual levels.
An information-guided approach to care — involving brain mapping, image post-processing and more — is leading to enhanced diagnosis and more-personalized treatments in patients with complex neurological diseases.
A novel PET radiotracer binds preferentially to myelin to provide unique brain imaging advantages over existing MRI methods. Here’s an overview of its backstory and clinical potential.
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Myelin PET offers quantitative imaging of brain microstructure that goes beyond what’s seen with current MRI methods. Here’s how we’re using it in epilepsy — and how we’ll soon be using it in other CNS diseases.
In medically intractable focal epilepsy, absence of a lesion on brain MRI too often rules out epilepsy surgery. This case shows how advanced diagnostics can allow “MRI-negative” patients to benefit from surgery.
This case of highly refractory epilepsy shows that SEEG-guided localization and surgery can bring significant seizure relief even in the setting of generalized or multifocal interictal discharges.
If patients with epilepsy don’t respond to one or more appropriately chosen medications, there may be a need for further, specialized treatment. Here, Imad Najm, MD, outlines alternative options for patients with epilepsy.
Recent Cleveland Clinic research shows increased expression of growth associated protein 43 (GAP-43) in dysplastic neurons, and an association between increased GAP-43 expression and longer epilepsy duration in patients with type II focal cortical dysplasia. These early findings suggest that GAP-43 may prove to be a pathology-specific biomarker for epileptogenicity and progression.
Combining scalp electroencephalography with functional magnetic resonance imaging may allow better understanding of the pathophysiologic mechanisms and patterns of epileptic activities.