TLR4: The Key to Cancer Stem Cell Evasion of Immune Suppression?

Through a side-by-side comparison of CSC and non-CSC reactions in specific TLR cultures, Dr. Lathia and his teams found that CSCs in GB have adapted to express a lower level of the innate TLR4. These diminished TLR4 levels allow the CSCs to persist and multiply, repopulating a tumor in a hostile microenvironment.

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