Locations:
Search IconSearch
June 2, 2019/Cancer

New Tool Accurately Measures Quality of Life in Colorectal Cancer Surgery Patients

Validation study finds survey fills an unmet need

650×450-Colorectal-Cancer-GettyImages-646161486

A new Cleveland Clinic-developed questionnaire reliably measures quality of life in colorectal cancer surgery patients, a validation study has found. Statistician Alexandra Aiello, MSPH, presented the results at the 2019 annual scientific meeting of the American Society of Colon and Rectal Surgeons.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

When compared with other available surveys, the Cleveland Clinic Colorectal Cancer Quality of Life (CCF-CaQL) questionnaire achieved validity in five key areas: construction, internal consistency, convergence, discrimination and responsiveness.

“The CCF-CaQL is a relatively concise survey covering content specific to the colorectal cancer surgery patient population,” says principal investigator and Cleveland Clinic colorectal surgeon Massarat Zutshi, MD. “We believe it will provide clinicians with a tool for predicting when complications are likely to occur, so they can counsel patients accordingly.”

Short and direct

A panel of experts developed the CCF-CaQL in response to the need for a comprehensive evaluation tool that took patients less time to complete than existing surveys, and that produced data more applicable to the colorectal surgery population.

The project was initiated more than a decade ago, when Cleveland Clinic was conducting a study comparing surgical procedures for colorectal cancer treatment. “We looked at all available questionnaires and found none was suitable,” says Dr. Zutshi.

Each questionnaire had strengths and weaknesses. None focused specifically on colorectal cancer surgery, and none provided a global quality-of-life score, since the areas of mental and physical health were covered separately.

To obtain a comprehensive score, patients had to fill out multiple questionnaires. Many questions did not apply to colorectal cancer or surgery, and the older tools did not take into account modern treatments that impact quality of life, such as chemoradiation and minimally invasive surgery.

Advertisement

“The surveys were either too general to be informative or too lengthy to complete,” says Dr. Zutshi

The solution was to develop a shorter but comprehensive and updated questionnaire that would enable clinicians to understand a colorectal surgery patient’s quality of life at any given point in time.

Useful and simple

The initial CCF-CaQL contained 26 questions focusing on quality of life, pain, bowel function and patients’ concerns about the future. It was tested in a pilot study involving 20 colorectal cancer patients and 20 controls. As a result of their input, one question was removed. The remaining 25-question survey proceeded to the validation study.

In this international validation study, the researchers administered three surveys — the CCF-CaQL, the Functional Assessment of Cancer Therapy-Colorectal Cancer (FACT-C) and the Short Form Health Survey (SF-12) — preoperatively and at six, 12 and 24 months postoperatively to 190 patients with low rectal cancer who were randomized to sphincter-sparing surgery with the J-pouch procedure or side-to-end anastomosis.

When the researchers compared the results, they found that more patients completed the CCF-CaQL than the FACT-C.

With fewer questions overall than the other two surveys, yet with questions specific to the colorectal surgery population, the CCF-CaQL provided accurate, useful data specific to quality of life following colorectal cancer surgery. At 24 months post-surgery, the CCF-CaQL was able to detect a significant difference between those patients who did and did not have complications (p < 0.001), highlighting its discriminative capability.

Advertisement

“The study validated our feeling that the new survey would enable us to measure treatment options at any point in time after surgery and know how well they are working,” says Dr. Zutshi.

The survey will be made available free of charge to interested physicians.

Advertisement

Related Articles

Dr. Khouri and patient
October 15, 2025/Cancer/News & Insight
BCL-2 Inhibition in Plasma Cell Disorders: The Work Continues

Preliminary results suggest combination therapy with lisaftoclax improves survival with few adverse events in patients with AL amyloidosis and relapsed/refractory multiple myeloma

Head and neck cancer illustration
October 6, 2025/Cancer/News & Insight
Blood-Based Assay Shows Promise for Personalizing Treatment in Head and Neck Cancer

New research demonstrates that cfDNA methylation patterns may noninvasively identify tumor hypoxia in head and neck squamous cell carcinoma

Head & neck image contouring
October 3, 2025/Cancer/News & Insight
Subspecialty Peer Review Improves Consistency, Quality and Safety in Head and Neck Radiation Therapy

Program reduces major contour changes and variations in organ-at-risk dosing across health system

Breast radiation therapy
October 2, 2025/Cancer/News & Insight
Study Confirms Breast Volume Preservation with Five-Day Radiation Therapy

No significant differences seen in breast volume loss between whole and partial breast treatment approaches

CT scan after prostate brachytherapy
October 1, 2025/Cancer/News & Insight
Clinical Outcomes for AI vs. Physician-Drawn Contours After Prostate Brachytherapy Comparable

Despite wide variations in contours, researchers find AI and physician methods yield equivalent results.

Dr. Mustafa Ali and patient
September 30, 2025/Cancer/News & Insight
Cytogenetic Response to Treatment Correlates With Long-Term Survival of Patients With Acute Myeloid Leukemia

New system refines classification of cytogenetic abnormalities at time of response assessment and their clinical significance

Ad