New research indicates that certain metabolites, such as fumarate, may serve as predictive biomarkers that could distinguish patients with PTEN mutations who will develop neurodevelopmental disorders from those who will develop cancer.
Hereditary syndromes that increase the risk of breast cancer are not common, but it is critical to recognize and manage them appropriately.
Patients with inherited cancer syndromes benefit from a Cleveland Clinic multidisciplinary referral network that provides a formal thyroid cancer screening process.
The discovery of cancer-predisposing gene mutations associated with Cowden syndrome and some apparently sporadic thyroid cancers highlights how cellular stress responses can be hijacked by cancer cells to promote their survival.
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A Cleveland Clinic study of patients with some features of Cowden syndrome and endometrial cancer shows that certain demographic and clinical features can predict the likelihood of harboring a PTEN or other gene mutation and serve as a catalyst for cancer genetic evaluation.