Treatment with a small-molecule TET inhibitor, TETi76, effectively suppresses the clonal evolution of TET2-mutant cells in mouse models and restricts the growth of TET-deficient leukemia in vivo.
Genetic Advances Fuel New Hope in Fight Against Myeloid Leukemias
The identification of multiple new genetic mutations, including those in the SETBP1 gene, which frequently mutate in a subset of leukemias, should bolster the development of innovative diagnostic and individualized therapies.