By extending traditional EEG-fMRI methods to 7T MRI, we’re markedly increasing detection sensitivity and temporal resolution of spikes to enable successful resection of the epileptogenic zone.
We’ve used DBS electrode stimulation during functional MR imaging to study seven patients to date with various neurological disorders. Here’s a glimpse of what we’ve learned.
Visual and postprocessing analyses with 7T MRI have the potential to yield substantial additional findings relevant to a patient’s epilepsy — and thereby increase candidates for curative surgery.
An 18-year-old with refractory “nonlesional” epilepsy undergoes 7T MRI and postprocessing to render his lesion more detectable. See how it impacts his evaluation, management and seizure profile.
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Comparative imaging studies are demonstrating superiority of 7T over 3T MRI in enhancing lesion conspicuity in patients with a range of neurological conditions. The likely bottom line: better diagnosis in many cases.
Few institutions use 7T MRI scanning in close relation with an active hospital. Here’s a glimpse of how Cleveland Clinic is leveraging its 7T scanner for clinical insights across a wide range of disorders.
Neural implants will soon play a role in treating various neurologic diseases, thanks to expert use of fMRI during electrode placement. Here’s how the technique is being applied for epilepsy, movement disorders and more.
Pairing fMRI with intracranial stimulation promises to better define a patient’s epileptogenic zone so surgeons can cure refractory focal epilepsy with a single procedure instead of multiple ones.
The recent introduction of combined PET-MRI scanning blends MRI’s superior spatial resolution with PET’s ability to detect changes in the brain’s metabolism in selected subregions. This is particularly useful in pediatric oncology and neurological disease. Simultaneous imaging reduces sedation use.
Deep brain stimulation (DBS) with real time intraoperative MRI lets surgeons assess lead location with anatomic landmarks instead of the microelectrode recording used during awake surgery. The intraoperative imaging allows DBS surgery to be done under general anesthesia, without patients needing to be awake for physiological measurements. Early Cleveland Clinic experience shows DBS leads implanted using intraoperative MRI varied only modestly from target placement, within expected error ranges.