A new report of complementary studies in humans and mice yields the best evidence to date linking gut bacteria to obesity. The findings have therapeutic implications for both obesity and type 2 diabetes.
Gut Microbe-Dependent TMAO from Dietary Choline Found to Be Prothrombotic in Humans
A new clinical study yields direct evidence of a mechanistic link between TMAO levels and clotting events. And it suggests that TMAO-induced platelet responsiveness can be attenuated by aspirin.
Gut Flora-Dependent TMAO: New Studies Extend Its Reach Beyond the Arteries to the Heart and Kidneys
When dietary choline and L-carnitine meet gut flora, the result is TMAO — and much unhealthful mischief. New research shows the damage goes beyond atherosclerosis to heart failure, chronic kidney disease and maybe more.
Heart Failure Outcomes Influenced by Diet and Gut Flora
Further research revealed heart failure patients with elevated plasma levels of TMAO, a metabolite generated in the gut, have a higher mortality risk than patients with lower TMAO levels.
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Gut Flora and Heart Health – A New Novel Pathway? (Video)
Researchers have found that a biochemical mechanism is at work between gut microbes and cholesterol that can lead to an increased risk of heart disease. They are looking more closely at a meat based diet vs. a plant based diet. Building on years of previous work, Dr. Hazen Stanley Hazen, Cleveland Clinic, and a research team are tracking the substance TMAO produced by the liver that is found to have an impact on negative cardiac outcomes.