August 25, 2020/Cancer

A 3-Way Comparison of Radical Cystectomy: How Do Patient Outcomes Compare?

Study examines open and robotic approaches for bladder cancer surgery


As robot-assisted radical cystectomy with intracorporeal urinary diversion (ICUD) has become an increasingly popular option in many high-volume centers, so too is the importance of comparing its outcomes to those of a more traditional open approach.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

In a recent Cleveland Clinic led study, researchers examined the outcomes and complications of patients who underwent three surgical approaches to radical cystectomy with urinary diversion. They published their findings in The Journal of Urology.

Robot-assisted cystectomy was popularized in the early 2000s and was touted as a less-invasive alternative to a traditional open cystectomy. Still, it’s not uncommon for some surgeons to take a hybrid approach, utilizing the robotic platform but reverting to an open approach for the urinary diversion part of the procedure, known as extracorporeal urinary diversion (ECUD). While more technically challenging, ICUD enables surgeons to more fully utilize the minimally invasive benefits of the robot for radical cystectomy.

“While ICUD is certainly an innovative approach utilized by bladder cancer surgeons, we recognize it’s not the only approach,” says Byron Lee, MD, PhD, a urologist in Cleveland Clinic’s Glickman Urological & Kidney Institute and senior author of the study. “In the context of patient outcomes, a direct comparison of these approaches is not well-described in the literature. That is what we hoped to contribute with this study.”

A closer look at the findings

The study examined the perioperative and pathological outcomes of 948 patients who underwent radical cystectomy with urinary diversion and bilateral pelvic lymph node dissection at Cleveland Clinic from 2011 to 2018.


This included 272 cases of open radical cystectomy (ORC), 301 with ICUD, and 375 with ECUD. Perioperative and pathologic outcomes were evaluated, as well as complications at 30- and 90-day intervals.

Notably, the authors found that estimated blood loss was lower for the ICUD method (p <0.001). Further, ICUD cases demonstrated shorter hospitalization (p <0.001) and a lower rate of postoperative ileus (p = 0.023), a common gastrointestinal complication associated with radical cystectomy.

In fact, overall, the study showed that the ICUD approach was associated with lower complication rates at 30- and 90-days, respectively, than the alternative procedures. However, readmission rates remained statistically similar among all three approaches.

To bladder cancer surgeons who favor the ICUD technique, these findings likely come as no surprise. “This research underscores what we have understood anecdotally for years,” says Dr. Lee. “Yes, the ICUD technique can be technically challenging, but there are significant clinical benefits for patients.”


When it comes to controlling cancer, research has shown that there is no significant difference between traditional open and robot-assisted modalities. With that in mind, Dr. Lee stresses that the best approach is often context-dependent and may simply depend on independent patient factors and the surgeon’s training and preference.

Although, studies like this that demonstrate comparative outcomes will likely support the continued use of ICUD within the field. Dr. Lee concludes, “It is a well-utilized technique at Cleveland Clinic, where we handle among the highest volumes of robot-assisted cystectomies using ICUD. We are committed to continue exploring minimally invasive techniques to improve patient outcomes and also to training the next generation of bladder cancer surgeons on this platform.”

Related Articles

Fluorescent imaging during small bowel surgery
April 11, 2024/Cancer/Surgical Oncology
Fluorescence Imaging Augments Surgical Inspection and Palpation for Small Bowel Carcinoid Tumors

Study demonstrates superior visualization of occult primary lesions

microwave ablation of liver tumor
150-Watt, Single-Antenna Microwave Ablation System Demonstrates Safety and Efficacy

New device offers greater tumor control for malignant liver lesions

viral-induced cancer
April 3, 2024/Cancer
Mechanism of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) May Serve as Clue to More Effective Treatment

Cleveland Clinic researchers discover what drives – and what may halt – virus-induced cancer

Dr. Mukherjee at Cleveland Clinic
April 1, 2024/Cancer/Blood Cancers
Many Patients with “Indolent” Systemic Mastocytosis Experience Rapid Decline and Lower Survival

First-ever U.S. population-level retrospective analysis reveals many patients with systemic mastocytosis need faster intervention

Cleveland Clinic physiatrist
March 22, 2024/Cancer/Innovations
The Vital Role of Oncology Rehabilitation (Podcast)

New program provides prehabilitation and rehabilitation services to help patients with cancer maintain and regain function

Doctors working on MGUS screening study
March 18, 2024/Cancer/Research
Pilot Study Aims for Early Identification of Multiple Myeloma Precursor Among Black Patients

First-of-its-kind research investigates the viability of standard screening to reduce the burden of late-stage cancer diagnoses

Hematologist at Cleveland Clinic
March 14, 2024/Cancer/Blood Cancers
Advances in Mantle Cell Lymphoma Treatment (Podcast)

Global R&D efforts expanding first-line and relapse therapy options for patients

Physician with patient
March 6, 2024/Cancer/Research
Targeting Uncontrolled Erythrocytosis in Polycythemia Vera with Rusfertide

Study demonstrates ability to reduce patients’ reliance on phlebotomies to stabilize hematocrit levels