January 3, 2023

Kidney Transplantation: Addressing the Organ Shortage by Improving Transplant Stewardship

Improving access to lifesaving kidney transplant

URL_Valleriano_3420447_Dr Wee_GUKI YIR_11-18-22_MLC

Approximately 90,000 patients in the United States are registered for a kidney transplant, according to data from the United Network for Organ Sharing (UNOS). The shortage of kidneys—and other lifesaving organs for transplantation—has led to urgent calls for improved organ utilization efforts worldwide.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Experts from Cleveland Clinic’s Kidney Transplant and Infectious Disease Programs continue to put forth protocols that guide transplantation for kidneys that may have been otherwise ineligible.

COVID-19 & kidney transplant: Leading practice-changing research

With limited guidance about best practices, transplanting extrapulmonary organs from deceased donors infected with SARS-CoV-2 has been controversial.

The Organ Procurement and Transplant Network (OPTN) Ad Hoc Disease Transmission Advisory Committee has emphasized balancing theoretical risk with potential waitlist-related complications or mortality. But with no other literature, transplant teams have had to take calculated risks.

In early 2021, the Kidney Transplant Team led by Alvin Wee, MD, MBA, Emilio Poggio, MD, and their infectious disease colleagues led by Christine Koval, MD, developed a protocol to perform kidney transplants from deceased donors who tested positive incidentally, without pulmonary issues. Continuing to monitor outcomes, they published their initial experience on 10 cases. Then they gradually expanded the criteria to include deceased donors with severe COVID-19 disease—as long as their kidney function was satisfactory.

Advertisement

Recently, the team published their experience of utilizing more than 100 kidneys from COVID-19-positive donors. In the American Journal of Transplantation, the authors report that from Feb. 1, 2021, to Jan. 31, 2022, they safely transplanted 115 adult kidneys from deceased donors with COVID-19. In total, 115 kidneys were transplanted from 68 donors with COVID-19, and 33 of these donors died from a COVID-19-related death.

Differences in graft performance and function were insignificant among the cohorts at a median follow-up of 5.7 months, regardless of SARS-CoV-2 status or severity. Recipients who received a kidney from a deceased donor with a COVID-19-related cause of death were associated with a lower—but still acceptable—estimated glomerular filtration rate at follow-up. Waiting time for an organ was shorter, the authors note.

Dr. Wee remarks: “Balancing the risk of accepting an organ with dying on the waitlist is always part of the decision when it comes to transplant, and the pandemic further complicated this. But this approach has enabled the transplant of more than 200 kidneys, a lifesaving intervention that may have been discounted otherwise. At the same time, this has also brought some meaning to the donor’s family from this senseless death.”

Only center in Ohio currently performing kidney transplant under the HOPE Act

In September 2022, Cleveland Clinic performed a kidney transplant from a deceased donor with HIV to a patient with end-stage kidney disease who is HIV positive, one of the first in Ohio to be performed under the HIV Organ Policy Equity Act (HOPE Act.)

Advertisement

The legislation is part of a national effort to make transplantation more accessible to patients with HIV, a patient population vulnerable to healthcare disparities, reversing a decades-long policy that prevented people with HIV from donating organs, explains Anita Modi, MD, Associate Staff in the Department of Infectious Disease.

Dr. Wee, who performed the surgery, says now that the regulatory groundwork has been established, they are eager to offer this option to candidates who are HIV-positive to improve their access to a lifesaving and life-changing procedure.

Related Articles

22-URL-3384771 CQD
January 13, 2023
Study Pinpoints US Geographic Hot Spots for Delayed Kidney Transplant Waitlisting Practices

Key findings and proposed clinical interventions for disparity areas

Human kidney on white background
December 28, 2022
Examining Dysnatremias in Patients With Chronic Kidney Disease

Investigators analyze dysnatremias using the Chronic Renal Insufficiency Cohort (CRIC) Study

22-URL-3418659 CQD 650×450
November 21, 2022
Unilateral Atrophic Kidney in a 45-Year-Old Woman

A case study in diagnosing and managing unexplained acute flank pain

Human Urinary System Kidneys Anatomy
November 10, 2022
Empagliflozin Is Safe and Effective in Patients With Chronic Kidney Disease

Cleveland Clinic nephrologist and site PI distills its significance and offers considerations

650×450-Virtual-Reality-Nakhoul
November 4, 2022
How a Virtual Reality Tool Is Enhancing Renal Physiology Education

Findings about the tool's utility were presented at the American Society of Nephology’s 2022 Annual Meeting

23-URL-3973558 CQD 650×450-B
July 11, 2023
Moving Closer Toward Narcotic-Free Kidney Transplantation

Smaller incision may lead to reduced postoperative pain for some patients

Masked Medical Appointment
March 21, 2022
Pilot Study to Create Automated Referral Process for Kidney Transplants

The process could improve access and equity for patients with end-stage kidney disease

Ad