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Nonobstetric surgery in pregnancy is rare and risky
By Moises Auron, MD, FAAP, FACP, SFHM, Marina Y Duran Castillo, MD, FACP and Omar Felipe Duenas Garcia, MD, MPH, FACOG
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*Please note: This is an excerpt from an article first published in the Cleveland Clinic Journal of Medicine. To view the article in its entirety, along with a complete list of references, please visit: https://www.ccjm.org/content/88/1/27.
Nonobstetric surgery during pregnancy should be avoided if possible, but when surgery is required, an obstetrician should be part of the perioperative team. In general, preoperative assessment is similar regardless of whether a woman is pregnant, but cardiovascular, pulmonary, hematologic and renal changes of pregnancy can increase surgical risk and must be taken into account. Special management considerations include pregnancy-associated laboratory changes, timing of surgery, anesthesia choice, intubation precautions, patient positioning, preoperative blood typing, intraoperative fetal monitoring and venous thromboembolism prophylaxis.
Important physiologic changes take place during pregnancy that optimize maternal and fetal outcomes but increase risk during surgery. Accommodating normal changes and identifying and managing risk factors should guide perioperative planning.
From 0.2% to 2.0% of pregnant women undergo nonobstetric surgery.1,2 In order of frequency, the most common procedures are appendectomy, cholecystectomy, adnexal surgery (for torsion or masses), trauma repair, small-bowel obstruction surgery and breast surgery.2–4
The American College of Surgeons National Surgical Quality Improvement Program reported a postoperative complication rate of 5.8% in pregnancy. Complications included reoperation within 30 days (3.6%), infections (2%), wound problems (1.4%), respiratory complications (2%), thromboembolic complications (0.5%), transfusion requirements (0.2%) and death (0.25%).4
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A study of 5,591 pregnant women in Taiwan5 found that the rates of the following postoperative complications were higher than among nonpregnant women:
One of the most common and feared complications from the obstetric perspective is preterm delivery. In a series of 86 pregnant women who underwent nonobstetric surgery in 1992 through 2014, the rate was 41% despite low rates of intraoperative and immediate postoperative complications.6
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Identifying risk factors for complications associated with induction of anesthesia is paramount. In addition to a physical assessment, clinicians should ask about personal and family history of bleeding disorders, coagulopathy and complications related to anesthesia (e.g., malignant hyperthermia).23
Risk of anesthetic morbidity and mortality in pregnancy are most associated with airway edema, restrictive lung physiology and aspiration.53 Other risk factors are eclampsia or preeclampsia, postpartum shock, pulmonary embolism, obesity, uncontrolled arterial hypertension and emergency surgery.54, 55
Increasing use of regional anesthesia instead of general anesthesia56 during delivery has led to reduced mortality. Hawkins et al57 found a 59% reduction (from 2.9 to 1.2 deaths per million patients) in anesthesia-related maternal mortality in the years 1991 to 2002 compared with 1979 to 1990. The relative risk of death during general anesthesia decreased from 6.7 before 1996 to 1.7 after that year. The improvements were associated with reduction in general anesthesia, as regional anesthesia rates increased during that time.
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