Prediction Model Estimates Anticipated Weight Loss from Four Common Anti-Obesity Medications

Shared decision-making tool published in a recent study fills void


Although there are now five FDA-approved anti-obesity medications (AOM) on the market, a lack of head-to-head trials comparing their effectiveness can make prescribing difficult. A new study from Cleveland Clinic addresses this paucity of real-world prescribing data with the creation of an anticipated weight loss calculator.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

“Physicians may be reluctant to prescribe AOMs for a number of reasons,” states Bartolome Burguera, MD, PhD, Chairman of Cleveland Clinic’s Endocrinology & Metabolism Institute and senior author on the paper. “Some may be uncertain which medication will work best for a particular patient or feel that there is not enough long-term experience with newer medications. Others physicians may not view obesity as a disease that warrants medical intervention, or may feel like they lack the time or training to treat obesity.”

Evaluating efficacy of anti-obesity medications

The retrospective study was designed to evaluate weight loss in more than 3,000 adults with BMI ≥30 kg/m2 and no related comorbidities, or ≥27 kg/m2 and at least one obesity-related comorbidity, such as hypertension, type 2 diabetes (T2D), cardiovascular disease or hyperlipidemia. Weight loss data was included for patients who received a 12-week prescription for an FDA-approved AOM along with lifestyle and behavioral interventions. Medications evaluated in this study included phentermine hydrochloride, phentermine-topiramate, bupropion-naltrexone and lorcaserin.

“We chose a 12-week interval to conform with the FDA’s ‘stopping rules,’ which call for a re-evaluation of weight loss medications in those patients who do not reach the 3-5% weight loss threshold within 12-16 weeks of use,” Dr. Burguera explains.


Patients in the study lost an average of 3.45% of their body weight from baseline over the 12-week treatment course. Although patients lost weight on all four medications, patients prescribed phentermine hydrochloride (loss of 3.75±5.66% of body weight) or phentermine-topiramate (3.63±5.7%) lost more weight than those taking lorcaserin (2.66±5.03%) or bupropion-naltrexone (1.84±6.69%). There was no statistically significant difference in percentage of weight loss in patients taking phentermine hydrochloride or phentermine-topiramate.

Patients lost less weight than in other trials, but still enough to make a difference in overall health

“We note several interesting findings in this study,” says Kevin Pantalone, DO, an endocrinologist and study author. “Patients were observed to have lost less weight in our study when compared to the weight loss that was observed in randomized-controlled trials evaluating the effectiveness and safety of AOM therapy. This may relate more to the design of our study than to the medications themselves, as medication costs were not offset in our study, we included patients with comorbidities, and we did not control for dose titration. In addition, as these medications are not routinely covered by most insurance plans, medication compliance in the real-world setting is often reduced and challenging to achieve.”

Although the magnitude of weight loss was less than other trials, approximately half of the patients lost at least 3% of their baseline body weight. According to Dr. Burguera, even this modest weight loss is enough to improve glycemic control, reduce cardiovascular risks, improve quality of life and keep patients motivated.


Note: Drs. Burguera and Pantalone would like to thank Kelly Shibuya MD for her help conducting this study during her tenure as a medical student at Cleveland Clinic Lerner College of Medicine.

Related Articles

Endocrinopathies from Checkpoint Inhibitors

Incidence, outcomes and management

Hyperglycemia in hospital setting
Multi-Pronged Strategies Key to Reducing Hospital-Related Hyperglycemic Events

Cleveland Clinic endocrinologists work to identify protocols for improving care

kidneys and diabetes
Kidney Disease in Diabetes: Updates and Recommendations

Cleveland Clinic’s Endocrinology & Metabolism Institute is working to offer novel opportunities and therapies for diabetes and kidney disease

Woman sleeping
Exploring the Relationship Between Sleep Amount and Type 1 Diabetes

New findings indicate the importance of achieving sufficient sleep levels in regard to personal glucose targets

Reexamining the Role of Preoperative Biochemical Values in Predictive Models in Primary Hyperparathyroidism

A recent study evaluates the correlation between preoperative calcium and parathyroid hormone values as predictors of gland volume and multi-gland disease

Keto-friendly dish
Ketogenic Diets in the Management of Type 1 Diabetes: Safe or Safety Concern?

As the diet’s popularity rises, certain considerations need to be taken when recommending it for patients with Type 1 diabetes

Diabetes care
Systematic Review Reinforces the Importance of Empowering Non-Physician Providers in Diabetes Care

Findings suggest that the effectiveness of interventions may depend more on the frequency and delivery methods of the intervention rather than who is delivering the intervention