James Church, MD, explains new research recommending flexible sigmoidoscopy screening beginning at age 40 in average-risk individuals, based on the steadily upsurging incidence of early-onset colorectal cancer and the left-sided predominance of CRC in these patients,
New Findings: Influence of High-Fat Diet on Colorectal Cancer
Cleveland Clinic researchers have identified a specific molecular pathway that plays a key role in the link between a high-fat diet and tumor growth in the colon.
Rectal Cancer Discoveries Show Promise for Predicting Neoadjuvant Responders
CAFs present in the rectal tumor microenvironment, when treated with radiation, increase the secretion of factors that contribute to tumor growth and cell migration. What this finding means for future treatment.
Multigene Panel Testing Reveals Mutations in Early Onset CRC Patients
A new study is the first using multigene panel testing to examine potentially important mutations among patients with early-onset colorectal cancer. Here’s how it suggests screening should change.
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Physician Collaboration Helps Design Ideal Patient Experience at New Cancer Building
Several surgeons, physicians and specialists helped design Cleveland Clinic’s new cancer building, creating an environment for efficient treatment and care for patients.
Jagelman Registries for Hereditary Colorectal Cancer Syndromes Prove Their Value Long-Term
By following multiple generations of families affected by hereditary colorectal cancer syndromes, Cleveland Clinic’s Jagelman Registries are preventing cancer mortality in the third generation.
Researchers Explore Using Tumor Gene Signatures to Determine Lymph Node Involvement Prior to Rectal Cancer Surgery
In order to make better treatment decisions for patients with rectal cancer, Cleveland Clinic researchers are exploring use of tumor gene signatures to more accurately determine lymph node status before surgery.
Cutoff Age for Universal Tumor Screening of Colorectal Cancer Misses Patients with Lynch Syndrome
Cleveland Clinic researchers find a significant number of colorectal cancer patients over age 70 have Lynch syndrome. Study supports universal tumor screening across all age groups to prevent cancers in future generations.
Researchers Find Possible Cause of Treatment Resistance in Colorectal Cancer
Cleveland Clinic research uncovers the influence of cancer-associated fibroblasts and secretion of the cytokine IL-17A on stem cell renewal, chemotherapy resistance and tumor spread in colorectal cancer.
Rectal Cancer Update: Study Validates AJCC/CAP Grading
While the AJCC/CAP Regression Grading scale for rectal cancer response was based on expert consensus, the clinical relevance of the scoring had not been validated — until a recent Cleveland Clinic study.