Phase 1 study found mutant calreticulin-specific monoclonal antibody brings promising results with no dose-limiting toxicities
Combination therapy doubles the number of meaningful spleen volume responses over monotherapy
Approach resulted in transfusion independence and durable anemia response
Study matches momelotinib against danazol
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Momelotinib, a new JAK inhibitor, inches closer to market approval
Dose-finding trial adds to evidence of efficacy
Interim results of phase 2 trial are promising
Second (or third) time’s a charm in reducing splenomegaly and other symptoms
Final results of PERSIST-2 confirm benefit; PAC203 enrolling
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