Locations:
Search IconSearch

Trigeminal Neuralgia: A Primer on Diagnosis and Treatment (Podcast)

Pharmacologic, procedural and surgical treatments abound

Trigeminal neuralgia, or tic douloureux, can cause sudden, sporadic and debilitating burning or shock-like pain in the face or head. While rare — affecting only four to five out of 100,000 people — it affects more women than men and is more common in older adults. Patients of any age require a thorough workup since trigeminal neuralgia can be triggered by multiple sclerosis or a brain tumor.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Emad Estemalik, MD, Section Head of Headache and Facial Pain in Cleveland Clinic’s Center for Neurological Restoration, discusses the challenges of diagnosing and treating this condition in the latest episode of Cleveland Clinic’s Neuro Pathways podcast.

His brief audio interview highlights the following:

  • How to make a correct diagnosis — including the main differential
  • The importance of multidisciplinary care in determining treatment
  • Options for surgical treatment and when to consider them

Click the player below to listen to the podcast now, or read on for a short edited excerpt. Check out more Neuro Pathways episodes at clevelandclinic.org/neuropodcast or wherever you get your podcasts.

Excerpt from the podcast

Dr. Estemalik: We always like to have patients first seen by one of our headache specialists or neurologists to ensure the accurate diagnosis has been made and the workup has been concluded. Patients should exhaust all pharmacological and procedural treatments before seeing a neurosurgeon. At a later point when, for instance, treatments are not working anymore, we discuss surgical approach.

The vast majority of patients do respond to the initial treatment, so that is good news. Some of the drugs that we use — like seizure medications, antidepressants and skeletal muscle relaxants — though they work, often have side effects. We try to work with the patient on the best medical option.

Then there are certain procedures that are very simple — like trigeminal nerve blocks and botulinum toxin injections — that also can provide pain relief. Our goal is to exhaust all these options before going to the next step, surgical intervention.

Advertisement

Again, we have a group of physicians, neurologists, headache specialists and surgeons who work closely together in setting the treatment plan.

The one thing we always tell our trigeminal neuralgia patients is that this is a chronic illness. We are not going to cure it right away, and it’s very, very likely that it’s always going to be there.

Advertisement

Related Articles

Two-dimensional scatter plot of peak T1 versus T2 times from pre-extended lumbar drainage MRI

MR Fingerprinting Predicts Shunt Efficacy in NPH

Study tests potential for a more accurate treatment predictor

person going into a Gamma Knife machine for radiotherapy
March 25, 2026/Neurosciences/Brain Tumor

Predicting Response to Stereotactic Radiosurgery for Recurrent Glioblastoma

Study uses molecular and clinical stratification to help guide patient selection

illustration of human brain with rumor at top right
March 23, 2026/Neurosciences/Brain Tumor

Adding Eflornithine to Lomustine Extends Survival in Recurrent IDH-Mutant Grade 3 Astrocytoma

Phase 3 STELLAR trial underscores role of molecular stratification in glioma care

brain MRI taken from the back of the head
March 20, 2026/Neurosciences/Epilepsy

Unmasking the ‘Tethered’ Temporal Lobe: New MRI Metrics Improve Detection of Encephaloceles in Refractory Epilepsy

Early identification of temporal encephaloceles can improve surgical decision-making

brain scan with white lesion on right side

ARISE II Recommendations Chart a Course for Advancing Intracranial Hemorrhage Care

Academia, industry and government leaders develop consensus priorities

two brain scans side by side with a yellow circle on the left scan
March 13, 2026/Neurosciences/Epilepsy

SEEG Linked With More Complete Resection and Greater Seizure Freedom in MOGHE Subtype of Epilepsy

Insights from one of the first studies of invasive monitoring in the rare form of focal cortical dysplasia

histopathology image with pink background and arrow pointing to round cell

New Insights on α-Synuclein Pathology and Clinical Phenotypes in Dementia With Lewy Bodies

The disease’s neuropathologic heterogeneity holds clues to refining diagnosis and prognosis

MRI of the brain against black background

Advanced Neuroimaging and Clinical Perseverance Make Sense of a 68-Year-Old’s Progressive Symptoms

A case study in pairing imaging acumen with subspecialty expertise to yield answers and symptom relief

Ad