November 10, 2020

Adrenal and Neuroendocrine Tumor Center Streamlines Care With Multidisciplinary Approach

Harnessing diverse expertise and advanced technology to treat complex tumor types

Neuroendocrine tumor micrograph

For the past two years, Eren Berber, MD, has worked with a team of multidisciplinary physicians to formalize Cleveland Clinic’s Adrenal and Neuroendocrine Tumor Center. Because of the complexity of neuroendocrine tumors (NET), patients with these tumors may require care from diverse specialists as the disease progresses. The Center helps coordinate these different services, develop clinical programs, advance research and incorporate the latest technology into care.


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The importance of long-term, multidisciplinary care

“Neuroendocrine tumors originate from neuroendocrine cells in the body, and these cells are different from most regular cancer cells,” says Dr. Berber, Professor of Surgery at Cleveland Clinic as well as Director of Robotic Endocrine Surgery, Surgical Liver Tumor Ablation and Co-Director of the Liver Tumor Ablation Program. “Although these cells are not as aggressive as other cancer cells, they need to be treated like cancer cells. NET patients have chronic disease, and they require multidisciplinary care, lifelong monitoring and intermittent treatment.”

Neuroendocrine tumors originate in the bowel, small or large intestines, pancreas, appendix, lungs or stomach. Patients with these tumors often present with a hormonal symptom, such as flushing of the face, diarrhea, respiratory problems or heart problems; treatment typically requires experts in many specialties. Physicians involved with the Center include specialists in endocrine surgery, oncology, radiology, cardiology, interventional radiology, general surgery, transplant, genetics and genomic medicine. When patients come to the Center, they will consult with a surgeon, an oncologist, a dietitian and others, all in a connected fashion.

“These patients require an endocrine expert to understand their hormonal physiology,” explains Dr. Berber. “They will need an oncologist to work them up and stage them for their tumors. They may also need unique drugs for their symptoms, such as somatostatin analogs, which work against the hormones that they produce and can alleviate symptoms. It is also likely that NET patients will need a surgeon to remove their tumors.”


Incorporating technology into care

One of the more unique aspects of this Center is its devotion to cutting-edge technology. “Cleveland Clinic has always had a very advanced multidisciplinary program,” says Dr. Berber. “There’s a lot of new technology for the diagnosis of these patients, such as DOTATATE PET imaging, for surgical treatments, such as robotic surgery, advanced liver tumor ablation technologies and new intraoperative imaging modalities with indocyanine green and for the oncologic treatment, such as peptide receptor radionuclide therapy.

Dr. Berber emphasizes two new technologies that have revolutionized the care of these patients:

  • Dotatate PET, a specialized PET scan, has been used at Cleveland Clinic for a couple of years. It’s considered the gold standard type of imaging for patients with neuroendocrine cancer.
  • Peptide receptor radionuclide therapy (PRRT), is a cancer treatment that uses targeted radiation based on the receptors that these neuroendocrine tumors house.

“The Center also has a multidisciplinary tumor board that meets every month,” says Dr. Berber. “The physicians are now much more connected. We talk to each other frequently to cover all clinical and research programs related to NET.”


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