LDLT for Severe Portal Hypertension: A Case Study

By Koji Hashimoto, MD, PhD

Living donor liver transplantation (LDLT) helps patients who don’t have priority on the transplant waiting list receive life-saving liver transplantation in a timely fashion.

Because a small, partial graft may cause small-for-size graft failure, the larger right lobe (65 to 70 percent of a whole liver) has been generally used in adult-to-adult LDLT worldwide. However, right lobe living donation has significant risks of morbidity and mortality in living donors.

Although the use of left lobe grafts (30 to 35 percent of a whole liver) is safer for living donors because the amount of liver volume taken from donors is smaller, the risk of graft failure is higher when a left lobe is used for adult recipients.

At Cleveland Clinic, we have achieved excellent outcomes in left lobe LDLT, and have particular experience in this field.

Vignette:

The patient is a 69-year-old male who had end-stage liver disease secondary to cryptogenic cirrhosis.

He had severe portal hypertension but did not have priority on the liver transplant waiting list. His friend became a living donor for him.

After comprehensive donor and recipient evaluation including 3-D simulation of liver anatomy, he received a left lobe graft with a graft-to-recipient weight ratio (GRWR) of 0.53 percent. Since the lowest limit of GRWR for LDLT is generally considered to be between 0.7 percent and 0.8 percent, there is no transplant center that routinely uses living donor grafts with a GRWR < 0.6 percent.

The patient did very well after transplant, without signs of small-for-size graft failure. A postoperative CT scan showed the left lobe graft has regenerated and now is as big as his native whole liver.

References:

1. Miller CM, Durand F, Heimbach JK, Kim-Schluger L, Lee SG, Lerut J, Lo CM, Quintini C, Pomfret EA. The International Liver Transplant Society Guideline on Living Liver Donation. Transplantation 2016;100:1238-1243.
2. Miller CM, Quintini C, Dhawan A, Durand F, Heimbach JK, Kim-Schluger HL, Kyrana E, Lee SG, Lerut J, Lo CM, Pomfret EA. The International Liver Transplantation Society Living Donor Liver Transplant Recipient Guideline. Transplantation 2017;101:938-944.