July 10, 2020

Multisystem Inflammatory Syndrome in Children: A Manifestation of COVID-19

What is known about how to manage patients who present with symptoms of hyperinflammation

650×450-COVID-Sick-Child

There are many unknowns about the risk factors, pathogenesis, prognosis and treatments for Multisystem Inflammatory Syndrome in Children (MIS-C), a Kawasaki-like manifestation of COVID-19 in some children.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Sirada Panupattanapong, MD, and Elizabeth B. Brooks, MD, PhD, of Cleveland Clinic Children’s Center for Pediatric Rheumatology, reviewed what is known about MIS-C in Cleveland Clinic Journal of Medicine’s COVID-19 Curbside Consults series.

Kawasaki disease

Kawasaki disease (KD) is an acute, self-limited illness that predominately effects young children. Symptoms can resemble acute infections, such as viral infection, bacterial lymphadenitis or scarlet fever. They include fever, extremity changes with erythema and edema of palms and soles or skin peeling, diffuse polymorphic rash, bilateral non-exudative bulbar conjunctivitis, cracked lips, oral and pharyngeal erythema, and cervical lymphadenopathy.

The authors write that “KD is the most common cause of acquired heart disease of children in the US and developed countries,” and note that 20% of untreated children can develop coronary artery aneurysm later in life.

Previously, children seemed to be asymptomatic or to develop mild symptoms with COVID-19 infection. Although MIS-C remains rare, it can be fatal.

Advertisement

A manifestation of COVID-19

Thought to occur two to three weeks after the peak of a local infection, the phenomenon appears to result from an uninhibited immune response to a prior COVID-19 infection rather than as a direct result of the acute viral infection. Most patients who develop these symptoms have a negative COVID-19 polymerase chain reaction nasopharyngeal swab test but positive viral serology, according to the authors.

Patients present with what the authors describe as “unrelenting fever” and gastrointestinal symptoms, along with other symptoms associated with classic KD. According to available data, several phenotypes are emerging: a combination of typical/atypical KD, Kawasaki shock syndrome, toxic shock syndrome and macrophage activation syndrome/hemophagocytic lymphohistiocytosis.

Management

MIS-C remains a rare phenomenon, and there is no established standard treatment guideline. The authors indicate that “early recognition is crucial as these patients may be critically ill and require care in a pediatric intensive care unit, as well as evaluation from multiple subspecialties, including infectious disease, cardiology, hematology/oncology and rheumatology.”

Key to the treatment of classic KD is intravenous immunoglobulin (IVIG), but may include cyclosporine and biologics for non-responders. High dose aspirin has also been used in conjunction with IVIG. The authors warn that “cardiogenic shock and myocardial compromise can lead to fatal outcomes,” and that “vigilant cardiac monitoring, serial cardiac markers (pro-BNP, troponin) and echocardiogram (focusing on cardiac function and coronary arteries) are also crucial.”

Advertisement

To read the entire review article, with a complete list of references, please visit: https://www.ccjm.org/cc/covid-19-curbside-consults.

Related Articles

Stellate Ganglion Block
May 17, 2023
Nerve Block Shows Promise for Long COVID-Related Olfactory or Gustatory Dysfunction

Patients report improved sense of smell and taste

Covid image
April 26, 2023
What Long COVID Means for Rheumatologists (Video)

Clinicians who are accustomed to uncertainty can do well by patients

Covid related skin effects
April 4, 2023
Cutaneous Manifestations of COVID-19 in Special Populations

Unique skin changes can occur after infection or vaccine

Glucometer
February 10, 2023
Effects of COVID-19 on Blood Sugar and Type 2 Diabetes

Cleveland Clinic analysis suggests that obtaining care for the virus might reveal a previously undiagnosed condition

covid-19
January 13, 2023
Optimal Management of High Risk Immunocompromised Patients in the COVID-19 Era

As the pandemic evolves, rheumatologists must continue to be mindful of most vulnerable patients

covid-19 virus
January 12, 2023
Real World Experience with Tixagevimab/Cilgavimab in B-Cell-Depleted Patients

Early results suggest positive outcomes from COVID-19 PrEP treatment

Eosinophilic Fasciitis
November 29, 2022
New Onset Eosinophilic Fasciitis after COVID-19 Infection

Could the virus have caused the condition or triggered previously undiagnosed disease?

COVID-19 and rash
June 16, 2022
Common Skin Signs of COVID-19 in Adults: An Update

Five categories of cutaneous abnormalities are associated with COVID-19

Ad