New Lobular Breast Cancer Registry Will Shed Light on Rare Disease

Lobular breast cancer is the second most common type of breast cancer from a histological perspective, but it only represents about 10 to 15 percent of breast cancer cases. Because of its rareness, oncologists have tended to view it and treat it in the same way as the more common ductal breast cancer.

But as more research is performed on lobular cancers, investigators are starting to recognize that it has some distinct features apart from ductal cancer, especially with respect to how it metastasizes and its decreased sensitivity to chemotherapy.

With this in mind, scientists from Cleveland Clinic, University of Pittsburgh Medical Center, Ohio State University and University Hospitals Cleveland Medical Center are creating a lobular breast cancer registry that will include cases from 1990 to the present.

“Many of us in the community feel like these cancers need some special attention,” says Megan Kruse, MD, Hematology and Medical Oncology, Cleveland Clinic. “That maybe it’s not best that we treat lobular breast cancer the same as ductal breast cancer. But the challenge in doing so is that lobular breast cancer cases are pretty rare, and so in order to really get a comprehensive look at its characteristics and treatment patterns, you really have to do it across multiple institutions.”

CDK4/6 Inhibitors and genetic changes

In addition to the new registry, Dr. Kruse says she also plans to soon start a genomics project around CDK4/6 inhibitors, a relatively new breast cancer drug, to see how the medication affects the DNA of both metastatic lobular breast cancer and metastatic ductal breast cancer.

“There is not that much information out there about what types of patients have the best response to these medications,” she says, “and how treatment with CDK4/6 inhibitors may alter genetic expressions in the cancer after treatment.

“So we’ll be looking to answer several questions: Can we identify any genomic predictors of which patients will respond best to therapy? How do we characterize the genomic changes we see after treatment? And will that give us an idea of how the cancers become resistant to treatment?”

Data shared at conferences

Dr. Kruse said she and other researchers at Cleveland Clinic area already gathering data on their lobular cancer patients for the registry — which she expects to contain data on 4,000 to 5,000 patients once it’s finished.

She hopes they have enough preliminary data to share some of it at the upcoming Great Lakes Breast Cancer Research Symposium. The group also plans to share information about the new registry at the San Antonio Breast Cancer Symposium next December.

“The registry will allow us to look in the aggregate at the characteristics of lobular breast cancer like size and hormone sensitivity,” she says. “It will also look at the type of treatments patients received: who got chemotherapy, who didn’t and how they responded. Finally we’ll also look at the genomics of these breast cancer cases to see if there’s a difference between what we expected and what we find.”

Image: MRI of breast. Source: NCI Visuals Online.