Orchialgia: A Common Problem with Sparse Research

Careful diagnosis, stepwise management can improve symptoms

By Daniel Shoskes, MD

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Orchialgia, also known as chronic testicular pain or chronic scrotal contents pain, is a condition that has long been a neglected diagnosis in urology.

Unlike most urologic men’s health conditions, we have limited data on incidence (although every practicing urologist who sees men knows that it’s common), no information on natural history, no validated symptom score/outcome measure, and no randomized controlled trials of medical therapy.

While data is sparse, we do know that a clear, stepwise approach to diagnosis and therapy can lead to improvement in many men.

Diverse etiology, but a clear path to treatment

Orchialgia may develop on its own or following infection, trauma, inflammation or surgery (e.g., vasectomy, hernia repair) or due to a hydrocele. Pain can also be referred to the scrotum from another source (e.g., a ureteral stone).

Clearly, any known reversible testicular cause should be diagnosed and treated. Pain due to pelvic floor muscle spasms is not difficult to appreciate on physical exam and can be treated with pelvic floor physical therapy. Other conservative measures are best to try for at least three months. These include rest, heat, tight-fitting underwear, oral anti-inflammatory medications (e.g., ibuprofen) and medications for neuropathic pain (e.g., gabapentin, pregabalin).

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Cord block diagnostic test

If pain persists, an important diagnostic test is injection of a local anesthetic into the spermatic cord at the level of the pubic tubercle. This cord block should anesthetize the genital branch of the genitofemoral nerve and inguinal branches of the ilioinguinal nerve. If the cord block doesn’t eliminate the pain, referral to a pain management physician may be warranted. Unfortunately, there is little outcome data regarding orchialgia treatment with chronic pain management approaches.

Surgical approaches

Microscopic spermatic cord denervation (MSCD). If the cord block is successful, eliminating the pain temporarily, we recommend MSCD performed through a subinguinal incision. In this outpatient surgery, the cord is exposed and using an operating microscope and meticulous microsurgical technique, the blood and lymphatic supply of the testicle are preserved and remaining structures, which contain the nerves, are transected. If a cord block was successful, the surgery provides durable cure of the pain in 75-80 percent of cases.

In this video, we demonstrate the MSCD technique.

Microscopic vasovasostomy. An alternative for men with postvasectomy pain is microscopic vasovasostomy. While its published outcomes are similar to MSCD postvasectomy, vasovasostomy does restore fertility and may only address pain in the subset of men who have congestive back pressure on the epididymis rather than neuropathic pain as their underlying pathophysiology.

At the Cleveland Clinic, our experience with MSCD is durable elimination of pain in slightly over 80 percent of patients. In the 20 percent who did not improve, several patients admitted that the cord block may not have eliminated their pain and several had pelvic floor spasm identified but declined doing physical therapy. Nevertheless, morbidity has been minimal with one hydrocele and one orchiectomy for persistent pain with poor arterial flow in the past 65 cases.

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Levine LA, Hoeh MP. Evaluation and management of chronic scrotal content pain.

Curr Urol Rep. 2015 Jun;16(6):36.

Larsen SM, Benson JS, Levine LA. Microdenervation of the spermatic cord for chronic scrotal content pain: single institution review analyzing success rate after prior attempts at surgical correction. J Urol. 2013 Feb;189(2):554-8.

Benson JS, Abern MR, Larsen S, Levine LA. Does a positive response to spermatic cord block predict response to microdenervation of the spermatic cord for chronic scrotal content pain? J Sex Med. 2013 Mar;10(3):876-82.