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Basic & Translational Science

medical device with inset image

Soft Robotic Model Replicates Patients’ Aortic Stenosis and Ventricular Dysfunction

Potential benefits include clinical guidance, TAVR outcome prediction, device testing

Idyllic neighborhood street, aerial view

Digital Twin Neighborhoods: An Advanced Tool to Tackle Health Disparities

Testable models of communities can identify effective strategies to address place-based inequalities of care

Erythritol is associated with susceptibility to heart attack

Sugar Substitute Erythritol Linked to Increased Cardiovascular Risk

Human and animal studies show a rise in platelet reactivity, thrombosis and cardiac events

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TREM2 Deficiency Hinders Recovery and Phagocytosis in Virus-Induced Demyelination

Model of viral encephalomyelitis shows links with CNS recovery from inflammation and damage

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National Prostate Cancer Trial Testing Therapy Based on Cleveland Clinic Molecular Discovery

Clinical trial strategy was developed through research on a gene associated with treatment-resistant prostate cancer

Brain research

Deep Learning Framework Unveiled for Identifying Risk Genes and Drug Targets in Alzheimer’s Disease

Open-source artificial intelligence technology uses human genetic data to find candidate drugs

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Transcriptomics-Based Study Suggests Metformin Is Repurposable for Atrial Fibrillation

Network proximity and EHR analyses identify diabetes drug as a top candidate for risk reduction

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Adjustable Soft Robotic Sleeve Mimics Complex Hemodynamics of Aortic Stenosis

Sophisticated in vivo modeling can enhance device development and therapy testing

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Big Patient Data Analyses Pinpoint Telmisartan as a Candidate Drug for Alzheimer’s in Black Adults

Findings underscore need for racial diversity in ongoing and future trials

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