October 16, 2017

Study Finds Bariatric Surgery Results in Bile Duct Dilation

Findings presented at WCOG at ACG2017


As rates of obesity have risen, so have the number of bariatric surgeries, making it one of the most common gastrointestinal (GI) operations worldwide. One of the most effective treatments for obesity, bariatric surgery not only promotes weight loss but also improves the management of diabetes, hypertension and metabolic disease. In 2015, Cleveland Clinic performed 655 bariatric surgeries, a number that is increasing each year.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Roux-en-Y gastric bypass (RYGB) is the most common bariatric surgery performed at Cleveland Clinic. Completing an RYGB operation involves re-routing the anatomy of the GI tract and the pathway food travels once ingested. The result is a small gastric pouch directly connected to the middle portion of the small intestine. Laboratory research has revealed that the positive effects of a gastric bypass operation are a result of more than just changes in anatomy — there are also profound changes in hormone and nerve signaling. These changes affect appetite, hunger and feelings of fullness, and alter the function of the pancreas, liver and bile ducts. They may also predispose patients to new morbidities.

Cleveland Clinic has developed expertise in techniques to evaluate and treat patients after bariatric surgery, since anatomical changes make it difficult to diagnose disease via routine endoscopy. The advanced procedures performed include endoscopic ultrasound (EUS) and laparoscopic-assisted transgastric endoscopic retrograde cholangiopancreatography (ERCP). Dilated bile ducts are a common indication for these procedures. When patients present with symptoms typical of diseases of the bile ducts, such as nausea, vomiting and pain in the right upper abdomen after eating, imaging studies are often ordered. Ultrasound, computed tomography (CT) or magnetic resonance imaging (MRI) may reveal dilated bile ducts, prompting further investigation with EUD and/or transgastric ERCP.

Some patients who have undergone transgastric ERCP at Cleveland Clinic had bile ducts that were dilated on imaging studies, but appeared relatively normal during ERCP, and specifically had no obvious cause for obstruction. It wasn’t clear if this symptom was due to surgery or an unrelated cause. Also, it wasn’t known whether this observation was specific to RYBG or followed any type of bariatric surgery.

Investigating changes in biliary diameter

To learn more about the relationship of bariatric surgery and bile duct diameter, Amit Bhatt, MD, led a team of Cleveland Clinic researchers that included members of the departments of General Surgery, Gastroenterology and Hepatology, Internal Medicine, and Diagnostic Radiology. Together, this multidisciplinary group and Quantitative Health Sciences, investigated whether a change occurs in common bile duct biliary diameter following RYGB and longitudinal sleeve gastrectomy (LSG).


The findings were presented this week at the World Congress of Gastroenterology at ACG2017 by Neal Mehta, MD, an internal medicine resident at Cleveland Clinic, from a study co-authored by Andrew Strong, MD, a general surgery resident at Cleveland Clinic.

The single center retrospective study assessed biliary diameter before and after RYGB and LSG based on ultrasound, CT or MRI. Common bile duct (CBD) diameter was measured at the same location both before and after bariatric surgery.

Study participants included 269 patients who had bariatric surgery (193 RYGB and 76 LSG) from January 2010 to December 2013 who had imaging studies before and more than three months after surgery. Patients with choledocholithiasis (gallstones in the common bile duct) and obstructive jaundice were excluded. The participants included 202 women and 67 men with a median age of 47 and median body mass index (BMI) of 46 kilograms per square meter. This group included 54 people who had a prior cholecystectomy, or gallbladder removal, a factor known to contribute to mild dilation of the common bile duct.

The study’s key findings

The results demonstrated that, after adjusting for pre-operative factors, subjects who underwent an RYGB had an increase in CBD diameter of 1.4mm (95% CI: 0.096 – 0.18), which was greater than the change following LSG 0.5mm (95% CI: – 0.007, 0.11). Biliary dilation occurred whether or not patients had previously undergone cholecystectomy.


“We will be managing more and more people with post-bariatric anatomy and we should be cautious in considering biliary dilation alone as a sign of bile duct pathology, and look for additional evidence before considering invasive procedures. We know that removing the gallbladder results in biliary dilation; the same may be true for bariatric surgery,” says Dr. Bhatt, the primary investigator and a gastroenterologist in the Department of Gastroenterology and Hepatology.

The research team is exploring the potential mechanisms causing bile duct dilation following bariatric surgery and considering the clinical implications of the finding. Current theories invoke some of the nerve and hormone signaling pathways altered after RYGB specifically; however, there appear to be other factors at play, since not every patient develops dilation to the same degree.

Related Articles

Doctor talking with patient
February 21, 2024
Consider Risk Factors When Deciding Care Path for Postoperative Crohn’s Disease

Strong patient communication can help clinicians choose the best treatment option

Federico Aucejo, MD
February 7, 2024
New Research Indicates Liver Transplant, Resection as an Option for Patients with CRLM

ctDNA should be incorporated into care to help stratify risk pre-operatively and for post-operative surveillance

Impostor phenomenon
February 6, 2024
Recognizing the Impact of Impostor Phenomenon and Microaggressions in Gastroenterology

The importance of raising awareness and taking steps to mitigate these occurrences

Koji Hashimoto, MD, and team
February 2, 2024
Combined Cardiac Surgery and Liver Transplant Is a New Option for Highly Selected Patients

New research indicates feasibility and helps identify which patients could benefit

Ajita Prabhu, MD
January 29, 2024
Case Study: Repair Surgery for Patient with Hernia and Abdominal Damage

Treating a patient after a complicated hernia repair led to surgical complications and chronic pain

December 8, 2023
MILU Improves Outcomes Among Critically Ill Patients with Advanced Liver Disease

Standardized and collaborative care improves liver transplantations

December 4, 2023
First Robotic Sleeve Gastrectomy Using Magnets in the US Performed at Cleveland Clinic

Fewer incisions and more control for surgeons

November 17, 2023
Younger Patients with Alcohol-Associated Hepatitis Present to the ED More Often, Research Shows

Caregiver collaboration and patient education remain critical