A new project is using tools from sleep research, neuroimaging, and blood and CSF biomarker analysis to study sex-specific influences of sleep and circadian rhythm disruption on neurocognitive decline.
Elevations in plasma triglyceride/HDL cholesterol ratio and plasma apolipoprotein A1 were associated with worse cognitive outcomes in a retrospective study of people with mild cognitive impairment or Alzheimer’s disease dementia.
New NIH-funded research combines analysis of blood-brain barrier changes with detailed characterization of AD-associated immunity changes. The aim is insights that lead to new avenues of therapy.
Application of the novel framework has identified the dyslipidemia medication gemfibrozil as a candidate drug to reduce Alzheimer’s disease risk.
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Two brain health experts discuss what the prominent study results mean for the amyloid hypothesis and what to expect next in both clinical practice and the research landscape.
A combination of pharmacoepidemiologic studies and Mendelian randomization genetic analysis revealed preferential protection in Black but not white individuals. The findings support ongoing studies of telmisartan for Alzheimer’s, particularly in racially diverse cohorts.
Many aspects of Alzheimer’s differ between the sexes. In this Q&A, an expert in the disease among women discusses recent research insights and where the field is likely headed.
A large insurance database analysis has found a 69% relative risk reduction for Alzheimer’s development over six years, prompting mechanistic and phase 2 randomized studies.
A network medicine study has identified mechanisms by which COVID-19 can lead to dementia-like cognitive impairment. The findings may help inform risk management and treatment strategies for COVID-19-linked dementia.
Both a characteristic clinical syndrome and positive amyloid beta and tau markers are needed for reliable diagnosis, advise new recommendations from an international expert group.