September 22, 2015

The Otology Lab: Pursuing Pioneering Research in Tinnitus and Hyperacusis

New models hope to advance understanding and treatment of these auditory disorders

14-ENT-2033-Kaltenbach-Hero-Image-690x380pxl

By James Kaltenbach, PhD

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Cleveland Clinic’s Auditory Neurobiology Laboratory has been on the cutting edge of hearing research ever since it was established in 2008. We were among the first to investigate the role of the cholinergic system in the modulation of tinnitus, and we continue to be pioneers in pharmacologic approaches aimed at treating this condition.

For example, we have succeeded in abolishing tinnitus-related hyperactivity in the dorsal cochlear nucleus, a component of the central auditory pathway that is key to tinnitus generation. We accomplished this by using a variety of cholinergic agonists in our in vivo tinnitus animal model. We are now moving toward the use of more selective molecules that will allow us to translate our therapeutic findings to the clinic. Preliminary results have been promising.

An Unprecedented Approach to Understanding Tinnitus

To further understand the effects of drug application on tinnitus-related neural activity, we are using innovative microscopic techniques to explore the anatomy and ultrastructural properties of tinnitus-generating neurons — the fusiform cells. By combining scanning electron microscopy with powerful computer software, we are able to accurately reconstruct the different layers and cellular components of the dorsal cochlear nucleus, where these neurons are located. Then we identify and trace individual neuronal elements, which allows us to generate 3-D renditions of the desired structures (Figure).

14-ENT-2033-Kaltenbach-Inset-Image-Fig-1-590pxl-width

Figure. 3-D reconstruction of a fusiform cell neuron (blue: cell body; yellow: apical dendrites; red: basal dendrites; white: axon).

Advertisement

This approach is unprecedented. It has allowed us to accurately map the fusiform cells, as well as the synapses on the different compartments of these neurons. Then we can examine the various features that provide measures of synaptic strengths (i.e., the sizes of synaptic terminals, the number of active zones within a synapse and the size of active zones).

The value of this information lies in its ability to define synaptic mechanisms that contribute to tinnitus and hyperacusis. It also provides us with a better understanding of the neuronal disequilibrium that occurs in the setting of tinnitus, as well as the mechanism of action of the drugs we use to abolish tinnitus-related hyperactivity.

Hyperacusis: In Search of Its Neural Signature

In addition to its long-standing history with tinnitus research, our lab has recently expanded its scope to cover yet another hearing condition: hyperacusis. Hyperacusis is a disorder of loudness perception in which sound intensities that are considered to be comfortable by most people are perceived as being unbearably loud, even painful, by affected patients.

We have recently established a first-of-its-kind animal model that exhibits chronic noise-induced hyperacusis and tinnitus simultaneously. Upcoming efforts are centered on establishing the first pure animal model of hyperacusis, which will allow us to accurately study the behavioral and neural correlates of hyperacusis. We expect this effort to pave the way for future research aimed at uncovering the neural signature of hyperacusis, which is essential if we hope to ever effectively treat or cure this condition.

Advertisement

Dr. Kaltenbach (kaltenj@ccf.org) is Director of Otology Research and Head of the Auditory Neurobiology Laboratory in the Head & Neck Institute. He is also a staff member in the Department of Neurosciences in the Lerner Research Institute.

Related Articles

Hoarseness
January 8, 2024
Hoarseness: When to Observe and When to Refer

Cleveland Clinic physicians weigh in

Mohamad Chaaban, MD
January 3, 2024
Obesity Increases Risk of Sinusitis — Independent of Asthma, Study Finds

New research adds to understanding of an understudied link

Figure 1
October 17, 2023
Case Study: Cholesteatoma

The rare condition can cause structural damage if untreated

Ehlers–Danlos Syndrome.
October 9, 2023
Cleveland Clinic Researchers Explore Laryngological Symptoms Among EDS Patients

A recently published case series highlights the broad range of laryngeal findings that can present among individuals with EDS

Osteoradionecrosis
September 14, 2023
ATLFL Rescue Flap Surgery Is Highly Successful at Halting Mandibular Osteoradionecrosis Progression With Low Associated Morbidity

Newly published research shows how the surgical technique is a game-changer for patients with ORN

Idiopathic Subglottic Stenosis
July 28, 2023
Study Compares Outcomes for Surgical Treatment of Idiopathic Subglottic Stenosis

First five-year prospective study provides valuable data to guide decision-making

Mohamad Chaaban
May 15, 2023
Study Explores Impact of Obesity on Chronic Rhinosinusitis Using State-of-the-Art BioRepository

The Head & Neck Institute will make its initial footprint in the newly constructed BioRepository building

hearing aids
February 20, 2023
New Research Highlights Connection Between Hearing Loss Interventions and Cognitive Decline

Hearing loss management has potential to improve more than just hearing health

Ad