Integrating advanced microscopy techniques with AI-fueled computational imaging promises to capture brain activity with the depth and speed needed to advance understanding of neurological diseases.
Read MoreResearch Links Immune Cell Receptors to Asthma, Inflammatory Lung Disease
A Cleveland Clinic research team has discovered how a protein on the surface of immune system mast cells in the lungs facilitates the cells’ proliferation, contributing to severe inflammation and progression to asthma. Although more research is needed to fully understand mast cell hyperproliferation, inhibiting the surface protein known as MCEMP1 could be a new approach to treating asthma and other inflammatory lung conditions.
Research Into How Cells ‘Self-Destruct’ Maps Out Body’s Defenses Against Viruses
Researchers at Cleveland Clinic’s Center for Pathogen & Human Health Research have identified a novel mechanism for how the body defends itself against viruses using programmed cell destruction.
Where We’re Headed with Vaccine Research: A Conversation with Ted Ross, PhD
The renowned virologist, who is Cleveland Clinic’s new Global Director of Vaccine Development, discusses his plans and priorities for the research post.
Research Aims to Prevent Future Pandemics
Two Cleveland Clinic Lerner Research Institute scientists are part of a national consortium developing new antiviral drugs to combat COVID-19 and prevent future pandemics.
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New Research Collaborative Aims to Close Minority Health Disparities
Cleveland Clinic researchers are organizing the Latino Epidemiology Cohort, a consortium that will investigate disease causes, risk and outcomes in underrepresented communities, initially focusing on Parkinson’s disease and colorectal cancer.
New Glioma Stem Cell-Related Target Identified for Potential Treatment of Glioblastoma
A preclinical study shows that inhibiting DNA-dependent protein kinase induces glioma stem cell differentiation and thereby sensitizes glioblastoma to radiation therapy.
Potential Target Identified for Treating Chemotherapy-Associated Kidney Damage
Recent findings that the protein molecule APE2 is implicated in cisplatin-related toxicity will be extended through new research grant funding aimed at pharmacologic interventions.
Researchers Identify New Drug Target for Treating Aggressive Prostate Cancer
Findings from a new study show that pharmacologically inhibiting the H6PD protein can reverse drug resistance in human-derived preclinical models of enzalutamide-resistant prostate cancer.
Identifying Actionable Cancer Mutations
Researchers have developed a personalized genomic medicine platform to identify clinically actionable mutations and accelerate the development of cancer precision medicine protocols.
Study Reveals Cause of Common Zika Virus Birth Defect
Defining the molecular mechanisms that drive the abnormal brain development associated with Zika virus infection.