October 18, 2017

First Trial of DBS for Stroke Recovery: Initial Patient’s Functional Progress Continues Through 5 Months

A trial status update and overview of investigational aspects

17-NEU-4268-Machado-CQD

By Andre Machado, MD, PhD, and Kenneth Baker, PhD

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

The first patient to ever undergo deep brain stimulation (DBS) to enhance motor rehabilitation following hemiparesis after ischemic stroke has experienced significant and steady functional improvements throughout the first five months of management pairing DBS with rehabilitative therapy. The 59-year-old woman had a DBS electrode surgically implanted in her cerebellum in December 2016 as the first participant in a first-in-human clinical trial of DBS for stroke rehabilitation, which is being conducted at Cleveland Clinic. This article briefly reviews the patient’s progress and our study’s rationale, design details and current status.

Essentials of the trial

Our trial is examining a novel strategy — stimulation of the dentatothalamocortical pathway to enhance excitability and plasticity across spared cerebral cortical regions — with the aim of promoting recovery of motor function following stroke. The primary hypothesis is that by applying DBS to the connections between the cerebellum and cerebral cortex, we can facilitate the plasticity that occurs in the surviving cortical regions around the stroke and thereby promote recovery of function beyond what rehabilitative therapy alone can accomplish.

For this initial trial, we plan to enroll 12 patients who, despite traditional rehabilitative therapy, have persistent, severe residual hemiparesis from an ischemic stroke 12 to 36 months earlier. In addition to the patient reported here, a second patient has undergone DBS electrode implantation but hasn’t completed enough subsequent therapy for results to be reported.

The study is being conducted solely at Cleveland Clinic with funding support from the National Institutes of Health’s BRAIN initiative.

Initial treatment protocol — and first patient’s response

The trial’s initial protocol began as follows:

  • One month of twice-weekly rehabilitative (physical plus occupational) therapy to establish baseline function
  • Surgery to implant the DBS electrode and battery
  • Four-week resting period at home to recover from surgery
  • Eight weeks of therapy without the DBS device turned on, to establish a new functional baseline
  • Four weeks of programming the DBS device with the aid of transcranial magnetic stimulation
  • Four months of therapy with the DBS device turned on continuously

Within a few weeks of when the DBS device was turned on, the trial’s first patient reported she could move her affected arm in ways she hadn’t been able to since her stroke (Figure 1). Her function has steadily and progressively improved ever since, as measured by the upper extremity subscale of the Fugl-Meyer Assessment of Motor Recovery after Stroke. She reports that she is now able to use her affected arm to cook, play games with her grandchildren, fold laundry and perform many other routine tasks. Her functional progress had not yet plateaued as of this writing, approximately five months after stimulation was started.

Figure 1. The trial’s first patient uses her affected arm in a therapy session four months after the start of stimulation.

Advertisement

Continuing improvement prompts protocol revision

The initial trial protocol called for a slow weaning from stimulation over the course of a month after completion of four months of concurrent DBS and physical therapy. However, continued progress by the first patient across even the fourth month of stimulation prompted us to obtain FDA approval to revise the protocol and extend therapy. Concurrent DBS and physical therapy will now continue for several additional months to afford the patient the opportunity for additional improvement, with stimulation weaned after nine months of treatment or when the patient’s motor improvement appears to have plateaued (whichever comes first).

Additional aspects of our investigation

In addition to the above functional outcomes that are the centerpiece of this trial, we are conducting many other investigations to better understand the relevant anatomy and refine the DBS technique used in this novel setting of stroke recovery. These investigations include the following:

7T magnetic resonance imaging (MRI). Each trial participant undergoes 7T MRI prior to surgery to allow optimal visualization of target brain structures. Our team’s engineers use these images to develop patient-specific models of the pathways that we are attempting to modulate in order to achieve the therapeutic goal. These 7T images and the resulting models will help create a guidebook to elucidate the relevant anatomy for neuromodulation for stroke rehabilitation moving forward. While postoperative 7T MRI evaluation would be valuable as well, the DBS device used is currently incompatible with MRI.

Serial positron emission tomography (PET). All patients undergo a series of four FDG-PET imaging studies — at enrollment, after DBS electrode implantation, during DBS treatment and a month after stimulation is turned off. These studies will test our hypothesis that metabolic activity along the brain pathway being targeted with DBS will increase in conjunction with any observed therapeutic improvements. Below is a baseline FDG-PET image from the trial’s first patient showing a right hemisphere stroke (Figure 2).

Figure 2. Baseline FDG-PET image from the trial’s first patient showing a right hemisphere stroke, as indicated by the reduced FDG uptake across that hemisphere (red signifies highest uptake, blue signifies lowest).

Intraoperative somatosensory evoked potential (SSEP) and electroencephalographic (EEG) testing. We are supplementing our initial 7T imaging guidance with intraoperative SSEP and EEG recordings at the time of DBS lead placement. These techniques may allow us to determine which electrical contacts along the octopolar lead are showing greater representation of motor-related neural activity and to assess changes in activity in response to acute stimulation in different areas. Given that neuromodulation for stroke rehabilitation — in contrast to movement disorders — does not allow immediate motor feedback once stimulation is started, this type of intraoperative testing can be invaluable in helping to determine which contacts to use for chronic therapy.

Transcranial magnetic stimulation (TMS) to assess cortical changes. Our team is using TMS as part of the acute programming sessions to assess whether DBS is enhancing excitability across the areas of cortex where we hope to achieve functional change. Additionally, TMS is being used to map the representation of motor activity for different regions of the body across those same spared cortical regions in order to identify whether any functional reorganization of the cortex is being achieved in response to therapy.

Advertisement

On the horizon

We also plan to introduce several additional assessments for trial participants going forward, including:

  • Non-motor testing by a neuropsychologist to ensure there is no disruption of cognitive processes involving the stimulated brain region
  • Use of a robotic device on which patients perform video game-like tasks to assess reaction and movement time, jerkiness of movement and similar performance measures

An additional goal is to initiate the development of paired associative stimulation paradigms that use the electrophysiological information that we record from the dentate nucleus to provide stimulation in a timing-dependent manner. The result would be a “smarter” closed-loop system that actively reinforces a patient’s attempted movements instead of relying on constant reinforcement.

Clearly, many questions remain, but we are encouraged by the positive results so far in our trial’s initial patient. We look forward to learning much more as this study continues.

Dr. Machado is a neurosurgeon and Chairman of Cleveland Clinic’s Neurological Institute.

Dr. Baker is a neuroscientist in the Department of Neurosciences in Cleveland Clinic’s Lerner Research Institute.

Related Articles

illustration of an alzheimer brain and a packet of sildenafil pills
March 11, 2024
Sildenafil as an Alzheimer’s Candidate Drug: Further Support From Insurance Database and Mechanistic Studies

Real-world claims data and tissue culture studies set the stage for randomized clinical testing

22-NEU-2959102-CQD-Hero-650×450
June 15, 2022
MINDS Study Will Assess Lifestyle Interventions for Slowing Brain Pathology in Preclinical Stages

New grant-funded investigation illustrates impact and reach of Cleveland Clinic Brain Study

22-NEU-2671014-CQD-650×450-Type
March 9, 2022
A Closer Look at the Cleveland Clinic Brain Study

How the new longitudinal investigation could become the Framingham Heart Study of brain health

20-NEU-1959738 powered-exoskeleton-for-gait-training_650x450
October 23, 2020
Study Signals Potential of Powered Exoskeleton for Gait Training in Multiple Sclerosis

Pilot findings show good patient acceptance and safety, early hints of efficacy

20-NEU-1990660-sleep-symptoms-in-health-workers-650×450
October 21, 2020
Electronic Screening for Sleep Disorders Among Healthcare Workers Is Feasible – and Sorely Needed

Study finds high prevalence of symptoms, willingness to seek treatment

20-NEU-1946228 neurofilaments_650x450
September 9, 2020
Serum Neurofilament Light as a Progressive MS Biomarker: Guideposts for the Road Ahead

Panel outlines research priorities around a promising alternative to imaging markers

20-NEU-1951118_Impella-temporary-LVAD_650x450_ (1)
September 4, 2020
Study Finds Clues to Acute Neurologic Events With Short-Term Impella Cardiac Support

Suspected factors include antithrombotic intensity, time on device, presence of thrombocytopenia

20-NEU-1929179 deep-brain-stimulation-for-TBI_650x450
September 3, 2020
Could DBS of the Cerebellar Dentate Nucleus Enhance Post-TBI Rehabilitation?

Preclinical studies will assess whether method developed for stroke recovery curbs deficits after brain injury

Ad