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Basic & Translational Science

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In Search of Predictive Biomarkers of Dementia in Parkinson Disease

$3.8M NIH grant fuels effort to develop a multimodal and multivariate model

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Studies of Sex-Related Molecular Differences in Glioblastoma Draw $10.4M in NIH Support

Funding expands work by consortium led by Cleveland Clinic Lerner Research Institute and CWRU

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Succession of Molecular Lesions Critical to Leukemia Disease Development

Mutational pattern in MDS is not random, study finds

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Team Creates Novel Zebrafish Model to Study Ewing Sarcoma

Paucity of models hinders development of treatments for this lethal disease

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NIH Awards $3M to Develop a Quicker, More Reliable Way to Diagnose Osteoarthritis

Research to investigate non-invasive method aims to identify patients at risk for osteoarthritis

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Genetic Factors May Influence COVID-19 Susceptibility

A possible association between ACE2 and TMPRSS2 polymorphisms and COVID-19 susceptibility

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Studies of an Alpha-1 Adrenergic Agonist for Alzheimer’s Advance With New NIA Grant

$2 million will enable preclinical dose and efficacy testing of “compound 3”

Genetic testing

Germline Genomic Profiles of Children, Adolescents and Young Adult with Solid Tumors Inform Management and Treatment

Largest-to-date evaluation of germline mutations in this population demonstrates the value of genetics evaluation and genetic testing

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What We’re Learning from the Brains and Spinal Cords of People with MS (Podcast)

Bruce Trapp, PhD, reflects on decades of basic and translational research

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