Marwan Sabbagh, MD, shares strategies for the differential diagnosis of dementia, along with implications of new developments like the advent of blood tests for the presence of brain amyloid plaques.
Tumor Necrosis Factor Pathway Contributes to Resilience in Alzheimer’s Disease
A genetic variant of the tumor necrosis factor receptor 2 pathway is associated with modulation of indicators of Alzheimer’s disease severity and slower functional decline. These cohort study findings hold promise for development of targeted therapies.
In Search of Disease-Modifying Treatment for Alzheimer’s (Podcast)
Most therapies in development for Alzheimer’s are focused on changing disease biology, with targets ranging from amyloid pathology to inflammation. A leader of our clinical trials program shares an update on drug development and diagnostics.
APOE ɛ4 Allele Presents With Varying Faces in Different Neurodegenerative Diseases
This risk gene increases the odds that initial symptoms will involve memory in patients with Alzheimer’s but not in those with Lewy body disease. So finds a large cohort study with implications for targeted therapeutics.
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Emerging Blood-Based Biomarkers for Alzheimer Disease: A Status Report
A screening blood test could accelerate drug development and enable earlier, more effective intervention. We offer an overview of promising efforts in pursuit of a reliable blood-based biomarker.