The factor Xa inhibitor failed to demonstrate noninferiority to warfarin in preventing valve thrombosis or thromboembolism in conjunction with the bileaflet On-X mechanical valve.
Left Atrial Appendage Closure Is Safe to Consider Even in the Very Elderly
In-hospital mortality following LAAC was no higher in patients aged 80 or older than in their younger counterparts, a large database analysis shows. We share insights on LAAC in this population from the Cleveland Clinic experience.
Analysis Reveals Considerable Off-Label Use of Direct Oral Anticoagulants After Heart Valve Replacement
Despite lack of labeling or much safety data, use of DOACs following surgical heart valve replacement is not insignificant — and is growing. So finds a new national cohort study.
Cleveland Clinic Children’s ECMO Honored for Excellence in Life Support
Continuous quality improvement efforts and support for caregivers lead to national recognition for extracorporeal membrane oxygenation (ECMO) at Cleveland Clinic Children’s.
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Thrombotic Complications of COVID-19: Principles for Treatment and Prevention
Severe COVID-19 is associated with a hypercoagulable state that often requires changes to usual inpatient anticoagulation strategies. We share our approach, including thromboprophylaxis protocols and a case vignette.
PROACT Xa Trial to Assess Non-Warfarin Anticoagulation After AVR With a Mechanical Valve
If this new prospective multicenter study meets its endpoints, aortic valve replacement with a mechanical valve will likely become more attractive to younger patients.
Toward an Evidence-Based Approach to Anticoagulation After Bioprosthetic AVR
A new PARTNER 2 analysis suggests a lack of short-term impact of early anticoagulation on hemodynamics and most clinical outcomes regardless of whether replacement was percutaneous or surgical. But definitive guidance awaits randomized investigation.
LAA Closure Device a Reality: Now What? (Video)
The newly approved WATCHMAN™ device can prevent stroke in high-risk patients with nonvalvular atrial fibrillation. But when exactly is left atrial appendage closure preferable to warfarin therapy?
Bringing New Thinking to the Treatment of Bicuspid Aortic Valve Disease
Two recent sizeable retrospective reviews yield insights from Cleveland Clinic’s more than three decades of experience repairing bicuspid valves and using bioprostheses for aortic valve replacement.