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Research

gut microbes in the human intestine

Gut Microbial TMAO Pathway Associated With Incident Heart Failure

Metabolites from animal product substrates implicated in heart failure development in community cohorts

chemical structure of erythritol drawn in a teaspoon

Evidence Mounts That Sugar Substitute Erythritol Raises Cardiovascular Risk

Study authors urge reevaluation of the sweetener’s safety designation by food regulators

x-ray of bone fracture in a forearm

TRAVERSE Substudy Links Testosterone Therapy to Increased Fracture Risk in Older Men With Hypogonadism

Surprise findings argue for caution about testosterone use in men at risk for fracture

photo of intubated elderly woman in hospital bed

Proteomic Study Characterizes Markers of Frailty in Cardiovascular Disease and Their Links to Outcomes

Findings support emphasis on markers of frailty related to, but not dependent on, age

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HVI_Kelley_4277155_Patient Procedure Shoot- First in Human Trial
October 27, 2023/Genomic Medicine

Cleveland Clinic Treats First Patient With Investigational Gene Therapy for Hypertrophic Cardiomyopathy

One-time infusion of adenovirus-based therapy is designed to restore heart muscle function

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Black Residents of Historically Redlined Areas Have Increased Heart Failure Risk

Large database study reveals lingering health consequences of decades-old discrimination

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Updates From CLEAR Outcomes and VALOR-HCM: Expanded Benefits With Bempedoic Acid and Mavacamten

Additional analyses of the two trials presented at 2023 ESC Congress

23-HVI-3972959_testosterone-and-the-heart_650x450

TRAVERSE Study Supports Cardiovascular Safety of Testosterone Therapy When Used as Indicated

But findings apply only to middle-aged or older men with confirmed hypogonadism

23-HVI-3853878_aortic-aneurysm_650x450

Study Identifies Gut Microbe-Derived TMAO as a Novel Mediator of Abdominal Aortic Aneurysm

Findings hold implications for screening and potential nonsurgical therapy

medical device with inset image

Soft Robotic Model Replicates Patients’ Aortic Stenosis and Ventricular Dysfunction

Potential benefits include clinical guidance, TAVR outcome prediction, device testing

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