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Research

LDL cholesterol particle with a DNA double helix on top of it

CRISPR-Cas9 Gene Editing for Refractory Dyslipidemia Shows Safety and Preliminary Efficacy

First-in-human phase 1 trial induced loss of function in gene that codes for ANGPTL3

Abdominal aortic aneurysm

Gut Microbe-Derived TMAO Can Predict Growth of Abdominal Aortic Aneurysm

Blood test can identify patients who need more frequent monitoring or earlier surgery to prevent dissection or rupture

electrocardiogram tracing

AI-Enhanced ECG Analysis Shows Strong Accuracy in Detecting Hypertrophic Cardiomyopathy

5% of flagged ECGs in real-world study were from patients with previously undiagnosed HCM

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gut microbes in the human intestine

Gut Microbial TMAO Pathway Associated With Incident Heart Failure

Metabolites from animal product substrates implicated in heart failure development in community cohorts

chemical structure of erythritol drawn in a teaspoon

Evidence Mounts That Sugar Substitute Erythritol Raises Cardiovascular Risk

Study authors urge reevaluation of the sweetener’s safety designation by food regulators

x-ray of bone fracture in a forearm

TRAVERSE Substudy Links Testosterone Therapy to Increased Fracture Risk in Older Men With Hypogonadism

Surprise findings argue for caution about testosterone use in men at risk for fracture

photo of intubated elderly woman in hospital bed

Proteomic Study Characterizes Markers of Frailty in Cardiovascular Disease and Their Links to Outcomes

Findings support emphasis on markers of frailty related to, but not dependent on, age

HVI_Kelley_4277155_Patient Procedure Shoot- First in Human Trial
October 27, 2023/Genomic Medicine

Cleveland Clinic Treats First Patient With Investigational Gene Therapy for Hypertrophic Cardiomyopathy

One-time infusion of adenovirus-based therapy is designed to restore heart muscle function

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