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Bench-to-bedside study identifies mechanism and potential therapeutic target
Elevated levels of the gut microbial metabolite predict prevalence and adverse outcomes in community-based study
Phase 1 trial shows up to 97% decrease through 48 weeks with good tolerability
Post hoc ALPACA analysis boosts biological rationale for ongoing outcomes trial of lepodisiran
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Durability findings propel potential one-time treatment approach to phase 1b testing
Findings promise to shape future antiplatelet drug development and treatment strategies
Robust signal from observational study raises prospect of a long-sought medical therapy
LLM-driven system uses both structured and unstructured data, provides auditable justifications
CD36 loss-of-function variant accounts for large portion of risk in this population
First-in-human phase 1 trial induced loss of function in gene that codes for ANGPTL3
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