Some patients with familial adenomatous polyposis treated with a combination of sulindac and eflornithine have a decreased risk of progression and a delayed need for lower gastrointestinal surgery.
Phase 3 Study Tests Sulindac/Eflornithine Combination for Familial Adenomatous Polyposis
Results of a new phase 3 study show promising results for a two-drug combination in reducing the need for surgery in patients with familial adenomatous polyposis (FAP).
Laparoscopic Reoperative Ileal J Pouch Anal Anastomosis: A Better Option?
Laparoscopic reoperative ileal J pouch anal anastomosis (IPAA) is feasible, safe and has better outcomes than laparotomy.
Should We Rethink Cancer Risk Staging in Familial Adenomatous Polyposis?
Cleveland Clinic research highlights the inconsistency of Spigelman classification as a risk predictor for duodenal cancer in familial adenomatous polyposis patients, suggesting that the formula for staging duodenal polyposis may need to be adjusted.
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Researchers Uncover Concerning Rise in Gastric Cancer, Despite Careful Monitoring, in FAP Patients
A surprising rise in gastric cancer among FAP patients caused physicians to change their surveillance techniques.
PTSD from Familial Adenomatous Polyposis Calls for Trauma Counseling
About 20 percent of FAP patients suffer from PTSD symptoms. James Church, MD, and his colleague performed groundbreaking research that demonstrates the need for specific trauma therapy.
Managing Lynch and FAP: A Balance Between Cancer Prevention and Quality of Life
As a GI, how do you make sound judgments to balance cancer prevention and quality of life in patients with inherited colorectal cancer predisposition syndromes? Here Dr. James Church explains Cleveland Clinic’s approach.
Prevalence of Thyroid Cancer in Cowden Syndrome and FAP Drives New Screening Recommendations
Patients with inherited cancer syndromes benefit from a Cleveland Clinic multidisciplinary referral network that provides a formal thyroid cancer screening process.