Succession of Molecular Lesions Critical to Leukemia Disease Development

Including genetic criteria, especially the clonal architecture, in leukemia classification will allow pathologists to identify the type of cancer being treated at a molecular level. This will allow clinicians to select certain drugs and avoid others based on disease type and make a more accurate prognosis for the course of the disease.

Learning from Leukemia

When Blood Breaks Down: Life Lessons from Leukemia, the new book by Cleveland Clinic oncologist Mikkael Sekeres, MD, MS, is a forthright, informative and moving account of what it’s like to be a leukemia patient and a leukemia doctor.

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A ‘Paradigm Shift’ in Conception of Aplastic Anemia

Cleveland Clinic researchers have identified gene mutations in some aplastic anemia patients that are associated with progression to myelodysplastic syndrome and/or acute myeloid leukemia. The mutations may trigger the immune response that results in aplastic anemia, and may also help mutated hematopoietic cells further proliferate.