Remission rates of elderly ALL patients on a novel, lower-toxicity immunotherapy regimen appear to at least equal those observed with conventional chemotherapy.
Study leads to FDA-approval of ivosidenib for patients with relapsed or refractory acute myeloid leukemia that have the genetic mutation IDH1.
Researchers uncover how the mutated NPM1 gene actually causes acute myeloid leukemia (AML). Their findings pave the way for targeted therapy for this largest subgroup of AMLs.
A new study shows that physicians may be overtreating patients with well-differentiated thyroid cancer and putting them at risk for more deadly diseases.
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Patients with relapsed/refractory ALL who were treated in a clinical trial with the antibody-drug conjugate inotuzumab ozogamicin experienced much higher remission rates compared with the standard of care, a new study reports.
The prognosis for ALL is poor and therapy has not changed for a decade. The drug inotuzumab ozogamicin now holds promise to change that outlook and improve outcomes.
Cleveland Clinic researchers have identified gene mutations in some aplastic anemia patients that are associated with progression to myelodysplastic syndrome and/or acute myeloid leukemia. The mutations may trigger the immune response that results in aplastic anemia, and may also help mutated hematopoietic cells further proliferate.
Several promising antibody-based treatment strategies are in development for acute lymphoblastic leukemia and acute myeloid leukemia. These could change the decade-old treatment paradigm.
Most cases of adult myeloid neoplasms, including myelodysplastic syndromes (MDS), have been presumed to occur sporadically. But Cleveland Clinic researchers identified a mutated gene, DDX41, associated with development of MDS, supporting the prospect of a familial predisposition mechanism behind such malignancies.
A transgender patient leads a doctor and his fellow to re-examine the traditional rigid rules of medicine and step outside their comfort zone when the issue of sexual orientation enters the exam room.