The five-year grant, led by Keith McCrae, MD, and Alok Khorana, MD, supports the creation of a new risk assessment tool to better predict which cancer patients will develop treatment-related thrombosis.
Nonlethal Targeting of Gut Microbes Inhibits Thrombosis with Minimal Bleeding Risk
Findings from a mouse model provide support for a new drug class that acts on gut microbes to reduce platelet responsiveness and thrombosis risk without promoting bleeding or antibiotic resistance.
Will Bioresorbable Scaffolds for Coronary Disease Pay Off Over the Long Term?
An FDA advisory panel just recommended approval of what may be the nation’s first bioresorbable stent. Here’s why an ABSORB III trial investigator wasn’t surprised that interim results didn’t find it superior to a standard DES.
Gut Microbe-Dependent TMAO Promotes Platelet Hyperreactivity, Raises Thrombosis Risk
Yet another cardiometabolic effect has been linked to the gut microbial metabolite TMAO: increased thrombotic risk stemming from platelet hyperreactivity. The lead Cleveland Clinic researcher discusses the implications.
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Doing More Is Not Always Better
Cleveland Clinic oncologist Alok Khorana, MD, discusses the appropriateness of cancer screenings in the wake of unprovoked thromboembolisms in a NEJM Editorial.
Study Finds New Predictors of Recurring Cancer-Specific Thrombosis
New analysis of the phase III CATCH trial of blood-thinning treatments identifies two clinical indicators for recurrent venous thromboembolism: tumor venous compression and hepatobiliary cancer.
3 Takes on 3 Emerging Strategies for Preventing Restenosis After Percutaneous Vascular Intervention
New developments promise further progress against restenosis and thrombosis after percutaneous vascular interventions. Cleveland Clinic interventionalists share perspectives on three leading developments.
Unique Thrombosis Center Coordinates Better Care
Specialized team focuses on research, reducing costs
Khorana Score Predicts Cancer Patients’ Thrombosis Risk
The Khorana score, named for its developer, Cleveland Clinic hematologist/oncologist Alok Khorana, MD, effectively forecasts cancer patients’ blood clotting risk based on a collection of simple variables — type of cancer, body mass index and complete blood count.