A Cole Eye Institute research team will study the role of inflammation in retinal regeneration in zebrafish, with support from a new four-year grant from the National Eye Institute.
Restoring the Retina: How to Regenerate Photoreceptors in Inherited Retinal Dystrophy
A study involving a zebrafish model of inherited retinal dystrophy finds that photoreceptors can regenerate when the notch3 gene is inhibited. In addition, immunosuppression can prevent the loss of photoreceptors.
Zebrafish Models Fuel Study of Pediatric Neutropenias
After having successfully created a zebrafish model to study Shwachman-Diamond syndrome (SDS), a rare inherited bone marrow failure syndrome that confers a high risk for developing myelodysplastic syndrome and acute myeloid leukemia, researchers at Cleveland Clinic are now turning their attention to other genetic disorders and cancers.
Team Creates Novel Zebrafish Model to Study Ewing Sarcoma
A pacuity of models hinders the development of treatments for Ewing sarcoma, a common and deadly pediatric cancer involving bone and soft tissues. To remedy this, researchers are creating zebrafish models that will enable the study of the biology of Ewing sarcoma.
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Regenerating the Retina
Using a novel thermal laser injury model, researchers observed the earliest response to injury in the zebrafish retina. The hope is to one day make regenerative retinal therapy in humans a reality.
Applying Retinal Regeneration in Zebrafish to Humans
Zebrafish are naturally able to heal damaged retinas and prevent scarring that can lead to loss of vision. Cleveland Clinic researchers hope to learn how to replicate that process in the human eye.
Basic Research: Tracking Down the Causes of Ciliopathies
Researcher studies what happens at the molecular and cellular levels when genetic mutations affecting cilia result in diseases that lead to the death of rod and cone photoreceptors in the eye.