A Cole Eye Institute research team will study the role of inflammation in retinal regeneration in zebrafish, with support from a new four-year grant from the National Eye Institute.
A study involving a zebrafish model of inherited retinal dystrophy finds that photoreceptors can regenerate when the notch3 gene is inhibited. In addition, immunosuppression can prevent the loss of photoreceptors.
After having successfully created a zebrafish model to study Shwachman-Diamond syndrome (SDS), a rare inherited bone marrow failure syndrome that confers a high risk for developing myelodysplastic syndrome and acute myeloid leukemia, researchers at Cleveland Clinic are now turning their attention to other genetic disorders and cancers.
A pacuity of models hinders the development of treatments for Ewing sarcoma, a common and deadly pediatric cancer involving bone and soft tissues. To remedy this, researchers are creating zebrafish models that will enable the study of the biology of Ewing sarcoma.
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Using a novel thermal laser injury model, researchers observed the earliest response to injury in the zebrafish retina. The hope is to one day make regenerative retinal therapy in humans a reality.
Zebrafish are naturally able to heal damaged retinas and prevent scarring that can lead to loss of vision. Cleveland Clinic researchers hope to learn how to replicate that process in the human eye.
Researcher studies what happens at the molecular and cellular levels when genetic mutations affecting cilia result in diseases that lead to the death of rod and cone photoreceptors in the eye.