6 Things to Know About the New Home of Our Neurological Institute

As 2026 draws to a close, Cleveland Clinic is putting finishing touches on the new Neurological Institute building it has constructed on its Main Campus in Cleveland. The 1 million-square-foot building (shown above) dramatically expands the physical infrastructure dedicated to neurological care on the campus and consolidates inpatient and outpatient neurological services under one roof. It also integrates a host of unprecedented technological design features. Yet those won’t be the facility’s most salient aspects, according to Neurological Institute Chief Andre Machado, MD, PhD.

“What is most notable about this building is not something structural but rather that it was wholly designed with people in mind — patients with neurological disease, their loved ones, and the clinicians and researchers caring for them,” Dr. Machado says. “Architecture is not about structures; it’s about people, and this building is designed for them. We want to provide our very talented team, and the additional talent we will recruit to this new facility, with the ideal spaces and technologies to deliver the best care possible today while simultaneously developing the neurological care of tomorrow. This facility will amass an enormous amount of concentrated knowledge, and we will put this critical mass to work toward new cures and the much-needed hope our patients and their loved ones seek.”

Consult QD asked Dr. Machado to flesh out details of the vision that shaped the conception and design of the building, which opens to patients in January 2027. He focused on six major aspects of that vision, as recapped below.

1) Customized for the experience of people with neurological disease

Because of substantial disability among many patients with neurological conditions, the building design puts an extra premium on accessibility, Dr. Machado says. Open spaces abound, and natural light has been maximized with floor-to-ceiling windows throughout. Patient flows are efficient and promote easy orientation. Wayfinding is intuitive, with no mazelike corridors.

Beyond that, leading-edge technology is ubiquitous, with examples detailed in some of the numbered sections below. “We want patients to perceive the building as a place of cutting-edge capabilities where emerging solutions are offered and where they can participate in the development of treatments of the future,” Dr. Machado explains. “Most of the conditions we treat are currently incurable, so providing patients with hope and empowerment is important to the experiential side of the design as well.”

2) Designed for digitization of care

As Neurological Institute stakeholders were planning the building’s design, they recognized a need to overcome some inefficiencies of traditional care processes, such as manual data entry and patients’ need to repeat details of the reason for their visit to various members of their care team.

“We had an epiphany,” Dr. Machado explains. “We realized that as a patient walks through the building, most aspects of their neurological examination could be acquired as they interact with the building and our caregivers. After all, the neurological exam is largely an exam of performance measures such as speed, reflexes, balance, cognitive function and language. Many of these measures can be captured by sensors and similar tools as a patient navigates the building. These can be transferred to the electronic health record and paint a picture of the patient’s neurological condition before the formal visit begins. We will spend less time asking patients how they’re doing and spend more of our valuable time together discussing what we can do to make things better.”

A prime example is the neurological assessment center, a centralized area where patients arriving for ambulatory visits complete a series of neuroperformance modules to objectively assess some key measures of neurological function, including gait, cognitive function, visuospatial processing, manual dexterity and voice pattern.

The intent is for a high level of data acquisition in the building, followed by immediate use of the data to enhance care, including distance health. Sensors in the building can be linked with patients’ performance measurements at home, captured via wearables and similar consumer technology. “As long as we evaluate the patient in the building every so often, we can co-register performance data obtained at home and validate those measures,” Dr. Machado notes.

This approach offers the advantage of assessing the function of patients who consent to participate at times when they don’t feel they’re being tested, so that the findings are not biased by a need to “perform” for an examiner. “The assessment will be more valuable because patients will be acting naturally and we can capture any deficits along the way,” Dr. Machado observes. “This type of assessment has never been done before at scale as part of routine clinical practice.”

3) Designed for distance health

The building is highly enabled to provide distance health, including digital connectivity with Cleveland Clinic sites across the nation and the world. These include the Lou Ruvo Center for Brain Health in Las Vegas and Cleveland Clinic hospitals in Florida, London and Abu Dhabi.

“The new building will serve as a hub and connector of knowledge” Dr. Machado says. “Its large-scale digital health capabilities can extend the depth of expertise to provide more subspecialized care elsewhere and help others with decision-making.”

He cites the example of Cleveland Clinic’s Epilepsy Center, where staff at the Main Campus have for years monitored seizure activity in patients from around the globe on a 24/7 basis through sophisticated digital connectivity. “This allows for nonstop seizure monitoring in hospitals that wouldn’t otherwise have the capability for it,” he explains. “The new building enables us to expand that monitoring further and offer similar distance health services at scale in additional subspecialty areas, providing expert care to as many people as possible.”

4) Designed for discovery

Planning sought to integrate research capabilities into clinical operations wherever feasible. “A big part of the building is dedicated not only to patient care but to human laboratories where we will test new diagnostics and treatments of the future,” Dr. Machado states.

He cites a number of examples:

• Neighboring spaces devoted to advanced clinical rehabilitation and to clinical research in neurorehabilitation, encouraging collaboration and cross-pollination
• An advanced therapeutics space for customized administration of both established and investigational drugs and cellular therapies for a wide range of neurological disorders
• A specialized unit for early clinical testing of novel surgical treatments such as new modalities of neuromodulation
• An advanced central monitoring unit that enables clinical care enhanced by novel methods of neurological monitoring and brain-signal processing
• Operating rooms equipped with next-generation intraoperative imaging and hybrid OR capabilities to facilitate innovative procedures and clinical trials
• Integration of technology throughout the building for streamlined capture of neuroperformance data to support and complement the Cleveland Clinic Brain Study

“The building will provide multiple interfaces between clinical care and research throughout,” Dr. Machado continues. “Routine neurological care will increasingly be delivered outside of the Main Campus. This building is where patients can participate in care that is not yet routine, where we can try new approaches and iterate them to develop new treatments.”

This care/research interface will be a significant draw for top clinicians and researchers, Dr. Machado believes. “This is where the future of neurological care will come from, and people will want to be part of that,” he says.

5) Fashioned for flexibility

Much of the building is modular in layout, with all spaces having a repetitive pattern based on standard ratios for patient rooms and outpatient offices. This makes it relatively easy to change the internal spaces based on changing needs or new technologies. “This flexibility will allow us to get the most out of this space as care evolves,” Dr. Machado explains.

The design also sidesteps the competition between clinical and administrative space by embedding within some exam rooms a partially shielded “nook” that can serve as a small office space for physicians. Outside of patient hours, a physician can open up the nook and have a larger office space if they wish. “The idea came from study nooks in old European buildings,” Dr. Machado notes. “It uses space more efficiently by avoiding the down time when either the physician’s office or the clinic space sits idle.”

6) Guided by clinicians

Neurological Institute clinicians — physicians, nurses, physical therapists and others — have been involved in every step of the building’s design. They’ve provided detailed feedback on various iterations of a mock facility with actual-size replicas of proposed room types filled with cardboard furniture and equipment.

“Our nurses have been particularly instrumental in giving us reality checks on what will be ideal for patients in terms of balancing privacy [every inpatient room is private] with safety and supervision,” Dr. Machado says. A prime example is the positioning of nursing stations between small windows that provide angled views inside two patient rooms at once to allow patient monitoring at any time.

Inventing tomorrow’s care

What excites Dr. Machado most about his institute’s new home? “We are charged with a dual mission,” he says. “We must do everything we can with what we have today for the patients in front of us now while also developing the neurological care of tomorrow. I believe this building and the talent that will inhabit it will enable discovery of the neurological care of the future. That’s what excites me most.”